Results 241 to 250 of about 29,514,683 (309)

High-flow nasal cannula versus continuous positive airway pressure for initial respiratory support in very preterm infants: study protocol for a multicenter randomized controlled trial (SIMPLSAFE3). [PDF]

Trials
Lamberska T, Jonas K, Borcinova M, Ophir Y, Plavka R.   +4 more
europepmc   +1 more source

Dynamically Actuated Reconfigurable Topographical Surface Enables Active Control of Implant‐Associated Infections

Advanced Functional Materials, EarlyView.
A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash, Jihun Lee, J. Scott VanEpps, Sungmin Nam, Jouha Min   +4 more
wiley   +1 more source

Strengthening pharmacovigilance and regulatory capacity in Southern Africa (SPaRCS): achievements, experiences and lessons learned from a participatory action learning project. [PDF]

Front Drug Saf Regul
Viljoen M, Khoza S, Dheda M, Chirinda L, Shigwedha F, Shimbulu A, Nhlabatsi S, Shongwe N, Figueras A, Ravinetto R, Bradley H.   +10 more
europepmc   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Effect of constraint standing training on balance and gait in hemiparetic stroke patients: a single-blind randomized controlled trial protocol. [PDF]

Trials
Zhou L, Chu H, Cao M, Rahim NAA, Yusof HA, Hou Y.   +5 more
europepmc   +1 more source

Thermoresponsive Soft and Self‐Anchoring Cuff Electrode for Chronic Peripheral Interfaces

Advanced Functional Materials, EarlyView.
A novel thermoresponsive, soft and self‐anchoring (TSSA) cuff electrode utilizing shape memory polymers achieves autonomous, sutureless peripheral nerve fixation. Driven by thermally induced pre‐strain and tissue adhesion, the device self‐closes and softens at body temperature, successfully minimizing mechanical mismatch. This adaptive platform ensures
Seungjun Lee, Byungwook Park, Jonghee Eun, Sohee Kim, Namsun Chou   +4 more
wiley   +1 more source

Ethical and Regulatory Frameworks for Artificial Intelligence in Clinical Research: A European Perspective on the Artificial Intelligence Act for Ethics Committees and Researchers. [PDF]

Eur Cardiol
Barucci A, Colcelli V, De Masi S, Falconi M, Carmela Leo M, Marzola A, Romagnuolo I, Sforzi C, Pini R.   +8 more
europepmc   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Optimal Clinical Trials Platform for Progressive Multiple Sclerosis (OCTOPUS): protocol for an international, multi-arm, multi-stage, platform, randomized controlled, double-blind, phase 3 clinical trial

Mangion SA, Wade C, Pugh C, Burnell M, Burton R, Rauchenberger M, Sweeney H, Nolan A, Lewis M, Brodnicki E, Hudson F, Hunter R, Bordea E, Abdel-Fahim R, Arun T, Broadley SA, De Angelis F, Doshi A, Foley P, Ford H, Galea I, Guadagno J, Hillier C, Kalra S, Kerrigan S, Leach O, Lyle D, Magill F, Mattoscio M, McDonell G, Pearson O, Pluchino S, Rice C, Sharrack B, Silber E, Spilker C, Yoga B, Adler A, Pavitt S, Fitzgerald D, Williams A, Scott S, Loveless S, Middleton R, Braisher M, Ciccarelli O, Barkhof F, Chandran S, Thompson A, Gray E, Carpenter J, Tallantyre E, Nicholas J, Parmar M, Chataway J.   +54 more
europepmc   +1 more source

Invest where impact begins: recommendations from Breast Cancer Research Foundation Early Career Investigator Working Group (Part 1 of 2). [PDF]

NPJ Breast Cancer
Abdou Y, Rozenblit M, Trapani D, Zerdes I, Boudreau E, Zhou Y, Adam V, Barrios C, Bousrih C, Branch V, Carey LA, Cameron D, Chen S, Chua BH, Davidson NE, Domchek SM, El-Abed S, El-Ashry D, Flowers M, Foldi J, Garber J, Goulioti T, Hodgdon C, Hung JL, Klar N, Norton L, Parajuli R, Piccart M, Pollastro T, Santa-Maria CA, Schumacher-Wulf E, Stecklein SR, Thulin A, Tovey H, Winer E, Wolff AC, Lin NU, O'Reilly S.   +37 more
europepmc   +1 more source