Results 71 to 80 of about 29,514,683 (309)

Ethics review of decentralized clinical trials (DCTs): Results of a mock ethics review. [PDF]

, 2022
Decentralized clinical trials (DCTs) can be a valuable addition to the clinical trial landscape. However, the practice of DCTs is dependent on a regulatory system designed for conventional (site-based) trials.
Trials@Home Consortium
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

ESTADO DEL ARTE EN LAS REVISTAS MÉDICAS EN EL SIGLO XXI

Revista Médica Clínica Las Condes, 2019
Resumen: Las revistas médicas publican manuscritos médicos científicos, verifican su autenticidad, diseminan su contenido y lo archivan. Ello las convierte en reflejos del estado actual de la medicina, repositorios de experiencias clínicas, vías de ...
Humberto Reyes
doaj   +1 more source

Financial considerations in the conduct of multi-centre randomised controlled trials: evidence from a qualitative study. [PDF]

, 2006
National Coordinating Centre for Research Methodology; Medical Research Council, UK Department of Health; Chief Scientist OfficeNot peer reviewedPublisher ...
Snowdon, Claire, Grant, Adrian M, Garcia, J, Francis, D, Francis, David, McDonald, Alison Mary, Knight, R.C, Elbourne, Diana, Knight, Rosemary, Elbourne, Diana R., McDonald, A.M, Grant, Adrian, Garcia Jo, Roberts Ian, McDonald Alison M, Elbourne, Diana R, Francis, David; id_orcid, Grant, Adrian Maxwell, McDonald, Alison M, Campbell Marion K, Entwistle, Vikki A, Snowdon, C, Campbell, Marion K, Campbell, M.K, Snowdon Claire, Entwistle, V.A, Campbell, Marion K., Francis David, Entwistle, Vicky, MacDonald, Alison M., McDonald, Alison, Grant, Adrian M., Grant Adrian M, Knight, Rosemary C, Knight, Rosemary C., Entwistle Vikki A, Roberts, Ian, Garcia, Jo, Grant, A.M, Campbell, Marion, Knight Rosemary C, Elbourne Diana R, Entwistle, Vikki A., Elbourne, D.R, Entwistle, Vikki, Campbell, Marion Kay, Roberts, I   +46 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Data Monitoring Committees and clinical trials: From scientific justification to organisation

Therapies
Clinical trials often last several months or even several years. As the trial progresses, it can be tempting to find out whether the data obtained already answers the question posed at the start of the trial in order to stop inclusions or monitoring earlier. However, knowing and taking into account interim results can sometimes compromise the integrity
Locher, Clara, Laporte, Silvy, Derambure, Peggy, Chassany, Olivier, Girault, Cécile, Avakiantz, Alix, Bahans, Claire, Deplanque, Dominique, Fustier, Pierre, Germe, Anne Françoise, Kassai Koupai, Behrouz, Lacoste, Louis, Petitpain, Nadine, Roustit, Matthieu, Simon, Tabassome, Train, Cecile, Cucherat, Michel   +16 more
openaire   +4 more sources

Understanding the functions and operations of data monitoring committees: Survey and focus group findings

Clinical Trials, 2017
Background: The use of data monitoring committees in the conduct of clinical trials has increased and evolved, but there is a lack of published information on when data monitoring committees are needed and utilized, the acceptable range of data ...
K. Calis, P. Archdeacon, Raymond P. Bain, A. Forrest, J. Perlmutter, D. DeMets   +5 more
semanticscholar   +1 more source

Questionnaires in clinical trials: guidelines for optimal design and administration. [PDF]

, 2010
A good questionnaire design for a clinical trial will minimise bias and maximise precision in the estimates of treatment effect within budget. Attempts to collect more data than will be analysed may risk reducing recruitment (reducing power) and ...
Edwards, Phil, Edwards Phil, Phil Edwards   +2 more
core   +2 more sources

sj-xlsx-2-ctj-10.1177_17407745231182417 – Supplemental material for Data monitoring committees in pediatric randomized controlled trials registered in ClinicalTrials.gov

, 2023
Supplemental material, sj-xlsx-2-ctj-10.1177_17407745231182417 for Data monitoring committees in pediatric randomized controlled trials registered in ClinicalTrials.gov by Tiago Machado, Beatrice Mainoli, Daniel Caldeira, Joaquim J Ferreira and Ricardo M
Ricardo M Fernandes (8344161), Joaquim J Ferreira (15463262), Tiago Machado (10205649), Beatrice Mainoli (10205646), Daniel Caldeira (4870822)   +4 more
core   +1 more source