Results 31 to 40 of about 41,285 (152)

Addressing the Maternal Mental Health Crisis Through a Novel Tech-Enabled Peer-to-Peer Driven Perinatal Collaborative Care Model

Voices in Bioethics, 2023
Photo by 193001056 © Yee Xin Tan on Dreamstime.com ABSTRACT Suicide and overdose, associated with perinatal mental health conditions, are the leading causes of maternal mortality in the United States.
Bridget McKinney
doaj   +1 more source

When participants get involved: reconsidering patient and public involvement in clinical trials at the MRC Clinical Trials Unit at UCL

Trials, 2018
Background Patient and public involvement (PPI) in clinical trials aims to ensure that research is carried out collaboratively with patients and/or members of the public.
Claire L. Vale, William J. Cragg, Ben Cromarty, Bec Hanley, Annabelle South, Richard Stephens, Kate Sturgeon, Mitzy Gafos   +7 more
doaj   +1 more source

A review of current practice in the design and assessment of internal pilots in UK NIHR clinical trials

Trials, 2019
Background Internal pilots provide useful information which can help to optimise the running of the main trial. Although some recommendations exist in the literature for the design of internal pilots, little is known about current practice in terms of ...
Anna Rosala-Hallas, Carrol Gamble, Jane Blazeby, Paula R. Williamson   +3 more
doaj   +1 more source

Subacromial spacers for adults with symptomatic, irreparable rotator cuff tears: the START:REACTS novel group sequential adaptive RCT

Efficacy and Mechanism Evaluation, 2023
Background A balloon spacer is a relatively simple addition to an arthroscopic debridement procedure for irreparable rotator cuff tears. Objective To evaluate the clinical and cost-effectiveness of a subacromial balloon spacer for individuals undergoing ...
Metcalfe Andrew, Arnold Susanne, Parsons Helen, Parsons Nicholas, Bhabra Gev, Brown Jaclyn, Bush Howard, Diokno Michael, Elliott Mark, Fox Josephine, Gates Simon, Gemperlé Mannion Elke, Haque Aminul, Hutchinson Charles, Kearney Rebecca, Khan Iftekhar, Lawrence Tom, Mason James, Rahman Usama, Stallard Nigel, Ul-Rahman Sumayyah, Viswanath Aparna, Wayte Sarah, Drew Stephen, Underwood Martin   +24 more
doaj   +1 more source

Online remote behavioural intervention for tics in 9- to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation

Health Technology Assessment, 2023
Background Behavioural therapy for tics is difficult to access, and little is known about its effectiveness when delivered online. Objective To investigate the clinical and cost-effectiveness of an online-delivered, therapist- and parent-supported ...
Chris Hollis, Charlotte L Hall, Kareem Khan, Marie Le Novere, Louise Marston, Rebecca Jones, Rachael Hunter, Beverley J Brown, Charlotte Sanderson, Per Andrén, Sophie D Bennett, Liam R Chamberlain, E Bethan Davies, Amber Evans, Natalia Kouzoupi, Caitlin McKenzie, Isobel Heyman, Joseph Kilgariff, Cristine Glazebrook, David Mataix-Cols, Eva Serlachius, Elizabeth Murray, Tara Murphy   +22 more
doaj   +1 more source

The role of the State Security Service (Stasi) in the context of international clinical trials conducted by western pharmaceutical companies in Eastern Germany (1961-1990).

PLoS ONE, 2018
BackgroundAfter the building of the Berlin Wall in the 1960s, a number of international pharmaceutical manufacturers from the West had their drugs tested in Eastern Germany (GDR). So far, the extensive collection of documents on the subject stored in the
Rainer Erices, Andreas Frewer, Antje Gumz   +2 more
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The International Council for Harmonisation E6 (R3) revision and its impact on clinical research practice: A narrative review

Cancer Research, Statistics, and Treatment
The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), established in April 1990, has released an updated version of its ICH E6 guidelines for Good Clinical Practice (GCP). This new version, ICH E6 (
Bhavesh A P Bandekar, Akriti Sood, Gargi Ganguly, Natasha Sisodia, Soumitra Saha, Akhil Kapoor, Satyajit Pradhan   +6 more
doaj   +1 more source

Selection bias in clinical stroke trials depending on ability to consent

BMC Neurology, 2017
Background Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not being able to give informed consent.
Benjamin Hotter, Lena Ulm, Sarah Hoffmann, Mira Katan, Joan Montaner, Alejandro Bustamante, Andreas Meisel   +6 more
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Comparison of the completed and discontinued pediatric drug clinical trials in Mainland China: a cross-sectional analysis based on the data from 2003 to 2023

BMC Pediatrics
Background Pediatric drug clinical trials are essential for ensuring the accessibility and safety of medications intended for children. In recent years, the Chinese government has implemented various measures to foster the development of pediatric drug ...
Zi-Ming Wang, Rui-Rui Du, Li Yang
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ESTADO DEL ARTE EN LAS REVISTAS MÉDICAS EN EL SIGLO XXI

Revista Médica Clínica Las Condes, 2019
Resumen: Las revistas médicas publican manuscritos médicos científicos, verifican su autenticidad, diseminan su contenido y lo archivan. Ello las convierte en reflejos del estado actual de la medicina, repositorios de experiencias clínicas, vías de ...
Humberto Reyes
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