Results 171 to 180 of about 1,156,853 (299)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Neuroimaging Compendium of Microglia, Amyloid, Tau, and Neurodegeneration Across Clinical Variants of Alzheimer Disease. [PDF]

Alzheimer Dis Assoc Disord
Houlihan H, Guzman D, Smith A, Sanchez T, Johnson A, Kreisl WC, Cosentino S, Noble JM, Lao P.   +8 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Diagnostic utility of tectal plate measures in clinical variants of progressive supranuclear palsy. [PDF]

J Neurol
Singh-Reilly N, Blakey M, Satoh R, Ali F, Pham NTT, Amrami A, Stephens YC, Dickson DW, Josephs KA, Whitwell JL.   +9 more
europepmc   +1 more source

Characteristics of Pruritus in Various Clinical Variants of Psoriasis: Results of the Multinational, Multicenter, Cross-Sectional Study. [PDF]

Life (Basel), 2021
Jaworecka K, Kwiatkowska D, Marek L, Tamer F, Stefaniak A, Szczegielniak M, Chojnacka-Purpurowicz J, Matławska M, Gulekon A, Szepietowski JC, Narbutt J, Owczarczyk-Saczonek A, Reich A.   +12 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Integrated Approach for Biochemical and Functional Characterization of Six Clinical Variants of Glucose-6-Phosphate Dehydrogenase. [PDF]

Int J Mol Sci
Hernández-Ochoa B, Gualos-González MG, Moreno-Hernández JA, Morales-Luna L, Vázquez-Bautista M, Canseco-Ávila LM, Pérez de la Cruz V, Arreguin-Espinosa R, Hernández-Urzua E, Enríquez-Flores S, De la Mora-De la Mora I, Cárdenas-Rodríguez N, Bandala C, De Franceschi L, Vidal-Limon A, Gómez-Manzo S.   +15 more
europepmc   +1 more source

Clinical variants of myocardial involvement in COVID-19-positive patients: a cumulative experience of 2020. [PDF]

Heart Fail Rev, 2022
Guglin M, Ballut K, Ilonze O, Jones M, Rao R.   +4 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Inhibitor Affinity Differs among Clinical Variants of IMP Metallo-<b>β</b>-Lactamases: Analysis and Implications for Inhibitor Design. [PDF]

ACS Infect Dis
Thomas CA, Alao JP, Smisek T, Cheng Z, Bethel CR, Yang K, Obaseki I, Page RC, Bonomo RA, Oelschlaeger P, Fast W, Kravats AN, Crowder MW.   +12 more
europepmc   +1 more source