Results 181 to 190 of about 126,662 (215)

The Nuclear Receptor Testicular Receptor 4 Orchestrates Cytoskeletal Organization in a G Protein Subunit Alpha 12/Rho‐Associated Protein Kinase–Dependent Manner to Promote Myofibroblast Differentiation and Tissue Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang, Lichong Shen, Junhui Zheng, Gisela Baur, Dilidaer Yasen, Honglin Zhu, Yi‐Nan Li, Xianyi Meng, Thuong Trinh‐Minh, Tim Filla, Debomita Chakraborty, Andrea‐Hermina Györfi, Christina Bergmann, Adam Reich, Alexander Kreuter, Georg Schett, Jörg H. W. Distler   +16 more
wiley   +1 more source

Automated MRI system for clinically significant prostate cancer detection development validation and real-world implementation. [PDF]

Nat Commun
Wu H, Liu F, Yang Q, Chen H, Wang Y, Yang X, Xia P, Fang L, Li G, Yang J, Luo Y, Li J, Fang X, Yang X, Jiang H, Liu J, Yi Y, Chai X, Lu J, Wang J, Gao X, Chen C, Shao C, Bian Y.   +23 more
europepmc   +1 more source

Risk of Cancer According to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study From the French Health Insurance Database

Arthritis &Rheumatology, EarlyView.
Objective To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes. Methods This nationwide cohort study used the French health insurance database to identify adults with SpA initiating a targeted therapy ...
Karine Tankovic, Pascal Claudepierre, Tat Thang Vo, Tran Trong Khoi Le, Siham Iggui, Laetitia Penso, Emilie Sbidian, Laura Pina Vegas   +7 more
wiley   +1 more source

Combining Serum Prostate Health Index With Urinary PCA3 and TMPRSS2:ERG RNA Testing Improves Detection of Clinically Significant Prostate Cancer. [PDF]

JU Open Plus
Eyrich NW, Huang Y, Zheng Y, Wei J, Sokoll L, Chan DW, Patil D, Chinnaiyan A, Tomlins SA, Lotan Y, Lin D, Scherr D, Wang Y, Kibel A, Taneja SS, Bidair M, Thompson IM, Sanda MG, Narayan VM.   +18 more
europepmc   +1 more source

Interactive pathology teaching on Instagram: Engagement outcomes from a 4‐week pilot study

Anatomical Sciences Education, EarlyView.
Abstract Social media is increasingly employed for medical education, yet Instagram remains under‐explored for visually rich disciplines, such as pathology. Using an established Instagram profile (@Patholife, >6000 followers), we delivered a structured, interactive educational series covering colorectal cancer, melanoma, and prostate cancer over a 4 ...
Madison T. Hindes, Ben S.‐Y. Ung, Maria C. Caruso   +2 more
wiley   +1 more source

PRIMA: randomized prospective multicenter non-inferiority study for primary diagnosis of clinically significant PRostate cancer by PSA and MR IMAging-study protocol for a randomized diagnostic accuracy trial. [PDF]

Trials
Al-Monajjed R, Albers P, Boschheidgen M, Radtke JP, Droop J, Benner A, Hadaschik B, Antoch G, Schimmöller L, PRIMA Study Group.   +9 more
europepmc   +1 more source

Status of oncology drugs with a conditional approval: A cross‐sectional comparison of the Food and Drug Administration and Health Canada

British Journal of Clinical Pharmacology, EarlyView.
Aims This study looks at the status of the same drugs conditionally approved by the Food and Drug Administration and Health Canada for the same oncology indication. Methods Lists of oncology drugs with a conditional approval from the Food and Drug Administration and Health Canada were generated and drug pairs with the same indication were matched ...
Joel Lexchin
wiley   +1 more source

Diagnostic Value of Transabdominal Ultrasound-based Versus Magnetic Resonance Imaging-based Prostate-specific Antigen Density for Clinically Significant Prostate Cancer. [PDF]

Eur Urol Open Sci
Xu Z, Song H, Huang H, Fu M, Tang Y, Zhang P, Zhang G, Li J.   +7 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Added value of systematic biopsy in patients with positive MRI-US fusion targeted biopsy for clinically significant prostate cancer: a single-center retrospective study. [PDF]

BMC Urol
Zhang J, Chen J, Jin J, Chen J, Zheng B.
europepmc   +1 more source