Results 31 to 40 of about 126,662 (215)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Evaluating the impact of radical prostatectomy and pathological upgrading on prognosis in non-clinically significant prostate cancer

Asian Journal of Surgery
Objective: Amidst growing medical concern about the risks of overtreatment in non-clinically significant prostate cancer (ncsPCa), this study aims to evaluate the impact of radical prostatectomy (RP) on the prognosis of ncsPCa patients, with a focus on ...
Jiahao Shan, Ziyang Liu, Qiang Zhang, Jin Yu, Hongbin Shi, Lianghong Ma   +5 more
doaj   +1 more source

Development and Validation of a Radiomics Nomogram for Predicting Clinically Significant Prostate Cancer in PI-RADS 3 Lesions

Frontiers in Oncology, 2022
PurposeTo develop and validate a radiomics nomogram for the prediction of clinically significant prostate cancer (CsPCa) in Prostate Imaging-Reporting and Data System (PI-RADS) category 3 lesions.MethodsWe retrospectively enrolled 306 patients within PI ...
Tianping Li, Tianping Li, Linna Sun, Qinghe Li, Xunrong Luo, Mingfang Luo, Haizhu Xie, Peiyuan Wang   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Freehand Transperineal Prostate Biopsy Improves the Detection Rate of Clinically Significant Prostate Cancer

Urology Research and Practice
Objective: Freehand transperineal prostate biopsy (fTP-Bx) has been established as an alternative within the transperineal approach for prostate cancer (CaP) diagnosis. The primary objective was to compare the rate of overall CaP detection and clinically
Juan Manuel Bujaldon, Gonzalo Juan Vitagliano, Leandro Blas, Martin Maqueda Vocos, Hernando Rios Pita   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Comparison of systematic and combined biopsy for the detection of prostate cancer

Asian Journal of Andrology
Systematic prostate biopsy has limitations, such as overdiagnosis of clinically insignificant prostate cancer and underdiagnosis of clinically significant prostate cancer.
Jin-Lun Huang, Da Huang, Tsun-Tsun Chun, Chi Yao, Yong-Le Zhan, Xiao-Hao Ruan, Terence Chun-Ting Lai, Chiu-Fung Tsang, Karl-Ho Pang, Ada Tsui-Lin Ng, Dan-Feng Xu, Brian Sze-Ho Ho, Rong Na   +12 more
doaj   +1 more source

A comparative study of transperineal software-assisted magnetic resonance/ultrasound fusion biopsy and transrectal cognitive fusion biopsy of the prostate

BMC Urology, 2022
Background The advantages and disadvantages of transperineal and transrectal biopsies remain controversial in the era of prostate targeted biopsy. In this study, we compared the cancer detection and complication rates of transperineal magnetic resonance ...
Po-Fan Hsieh, Tian-You Chang, Wei-Ching Lin, Han Chang, Chao-Hsiang Chang, Chi-Ping Huang, Chi-Rei Yang, Wen-Chi Chen, Yi-Huei Chang, Yu-De Wang, Wen-Chin Huang, Hsi-Chin Wu   +11 more
doaj   +1 more source