Results 191 to 200 of about 9,169,598 (279)
Age‐Associated Four‐Gene Prognostic Signature in Breast Cancer
Cancer Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background
Young‐onset breast cancer is associated with inferior disease‐free survival (DFS), but the contribution of additional molecular heterogeneity remains unclear. Aims
To identify an exploratory age‐associated gene expression signature linked to recurrence‐related outcomes and evaluate its prognostic association.Shiro Uchidawiley +1 more sourceGWAS of Tau‐Neurodegeneration Mismatch Identifies New Risk Loci for Susceptibility to Tau
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.This GWAS of tau/neurodegeneration mismatch in 794 ADNI and A4 participants identified two genome‐wide significant loci, STXBP6 and AKAP9. The risk alleles were associated with greater‐than‐expected neurodegeneration for a given tau burden, suggesting these genes may influence susceptibility to tau‐related neuronal injury.Fardin Nabizadeh, Hanieh Mohamadi, for the Alzheimer's Disease Neuroimaging Initiative (ADNI), Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowski, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Lew Kuller, Marcus Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, David Holtzman, Marek M. Mesulam, William Potter, Peter Snyder, Adam Schwartz, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Paul Thompson, Norbert Schuff, Bret Borowski, Jeff Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward, Robert A. Koeppe, Norm Foster, Eric M. Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J. Cairns, Erin Householder, Lisa Taylor‐Reinwald, Virginia Lee, Magdalena Korecka, Michal Figurski, Karen Crawford, Scott Neu, Tatiana M. Foroud, Steven G. Potkin, Li Shen, Kelley Faber, Sungeun Kim, Kwangsik Nho, Leon Thal, Neil Buckholtz, Marylyn Albert, Richard Frank, John Hsiao, Jeffrey Kaye, Joseph Quinn, Betty Lind, Raina Carter, Sara Dolen, Lon S. Schneider, Sonia Pawluczyk, Mauricio Beccera, Liberty Teodoro, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Judith L. Heidebrink, Joanne L. Lord, Sara S. Mason, Colleen S. Albers, David Knopman, Kris Johnson, Rachelle S. Doody, Javier Villanueva‐Meyer, Munir Chowdhury, Susan Rountree, Mimi Dang, Yaakov Stern, Lawrence S. Honig, Karen L. Bell, Beau Ances, Maria Carroll, Sue Leon, Mark A. Mintun, Stacy Schneider, Angela Oliver, Daniel Marson, Randall Griffith, David Clark, David Geldmacher, John Brockington, Erik Roberson, Hillel Grossman, Effie Mitsis, Leyla de Toledo‐Morrell, Raj C. Shah, Ranjan Duara, Daniel Varon, Maria T. Greig, Peggy Roberts, Chiadi Onyike, Daniel D'Agostino, Stephanie Kielb, James E. Galvin, Brittany Cerbone, Christina A. Michel, Henry Rusinek, Mony J. de Leon, Lidia Glodzik, Susan De Santi, PMurali Doraiswamy, Jeffrey R. Petrella, Terence Z. Wong, Steven E. Arnold, Jason H. Karlawish, David Wolk, Charles D. Smith, Greg Jicha, Peter Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Oscar L. Lopez, MaryAnn Oakley, Donna M. Simpson, Anton P. Porsteinsson, Bonnie S. Goldstein, Kim Martin, Kelly M. Makino, MSaleem Ismail, Connie Brand, Ruth A. Mulnard, Gaby Thai, Catherine McAdams‐Ortiz, Kyle Womack, Dana Mathews, Mary Quiceno, Ramon Diaz‐Arrastia, Richard King, Myron Weiner, Kristen Martin‐Cook, Michael DeVous, Allan I. Levey, James J. Lah, Janet S. Cellar, Jeffrey M. Burns, Heather S. Anderson, Russell H. Swerdlow, Liana Apostolova, Kathleen Tingus, Ellen Woo, Daniel H. S. Silverman, Po H. Lu, George Bartzokis, Neill R. Graff‐Radford, Francine Parfitt, Tracy Kendall, Heather Johnson, Martin R. Farlow, Ann Marie Hake, Brandy R. Matthews, Scott Herring, Cynthia Hunt, Christopher H. van Dyck, Richard E. Carson, Martha G. MacAvoy, Howard Chertkow, Howard Bergman, Chris Hosein, Ging‐Yuek Robin Hsiung, Howard Feldman, Benita Mudge, Michele Assaly, Charles Bernick, Donna Munic, Andrew Kertesz, John Rogers, Dick Trost, Diana Kerwin, Kristine Lipowski, Chuang‐Kuo Wu, Nancy Johnson, Carl Sadowsky, Walter Martinez, Teresa Villena, Raymond Scott Turner, Kathleen Johnson, Brigid Reynolds, Reisa A. Sperling, Keith A. Johnson, Gad Marshall, Meghan Frey, Barton Lane, Allyson Rosen, Jared Tinklenberg, Marwan N. Sabbagh, Christine M. Belden, Sandra A. Jacobson, Sherye A. Sirrel, Neil Kowall, Ronald Killiany, Andrew E. Budson, Alexander Norbash, Patricia Lynn Johnson, Joanne Allard, Alan Lerner, Paula Ogrocki, Leon Hudson, Evan Fletcher, Owen Carmichae, John Olichney, Charles DeCarli, Smita Kittur, Michael Borrie, T.‐Y. Lee, Rob Bartha, Sterling Johnson, Sanjay Asthana, Cynthia M. Carlsson, Adrian Preda, Dana Nguyen, Pierre Tariot, Stephanie Reeder, Vernice Bates, Horacio Capote, Michelle Rainka, Douglas W. Scharre, Maria Kataki, Anahita Adeli, Earl A. Zimmerman, Dzintra Celmins, Alice D. Brown, Godfrey D. Pearlson, Karen Blank, Karen Anderson, Robert B. Santulli, Tamar J. Kitzmiller, Eben S. Schwartz, Kaycee M. Sink, Jeff D. Williamson, Pradeep Garg, Franklin Watkins, Brian R. Ott, Henry Querfurth, Geoffrey Tremont, Stephen Salloway, Paul Malloy, Stephen Correia, Howard J. Rosen, Bruce L. Miller, Jacobo Mintzer, Kenneth Spicer, David Bachman, Stephen Pasternak, Irina Rachinsky, Dick Drost, Nunzio Pomara, Raymundo Hernando, Antero Sarrael, Susan K. Schultz, Laura L. Boles Ponto, Hyungsub Shim, Karen Elizabeth Smith, Norman Relkin, Gloria Chaing, Lisa Raudin, Amanda Smith, Kristin Fargher, Balebail Ashok Raj, Thomas Neylan, Jordan Grafman, Melissa Davis, Rosemary Morrison, Jacqueline Hayes, Shannon Finley, Karl Friedl, Debra Fleischman, Konstantinos Arfanakis, Olga James, Dino Massoglia, JJay Fruehling, Sandra Harding, Elaine R. Peskind, Eric C. Petrie, Gail Li, Jerome A. Yesavage, Joy L. Taylor, Ansgar J. Furst +305 morewiley +1 more sourceEvaluation of methods to classify ipsilateral breast tumour recurrences as local recurrence or new primary tumour. [PDF]
NPJ Breast CancerBlacker S, Boyle JM, Wang L, Withrow DR, Delon C, Dodwell D, Verrill M, Lemanska A, Pinder SE, Frampton AE, Horgan K, Cromwell DA. +11 moreeuropepmc +1 more sourceCDO1 as a prognostic biomarker and therapeutic target in gastric cancer: Mechanistic insights into the PI3K/AKT‐THBS1 axis and epigenetic reactivation by decitabine
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.CDO1 is a tumour suppressor in gastric cancer that directly binds PI3K p85α, disrupting p85α–p110α dimerization to inhibit the PI3K/AKT–THBS1 axis. Decitabine epigenetically restores CDO1 expression and exerts CDO1‐dependent anti‐tumour activity, synergizing with 5‐FU. Abstract Background
As a pivotal metabolic enzyme, cysteine dioxygenase type 1 (CDO1)Fazhi Wang, Runkai Zhou, Jinfeng Cai, Jiazhe Wen, Abudushalamu Yalikun, Yang Yu, Yugang Wen +6 morewiley +1 more sourcePRMT7‐mediated arginine methylation of FOXK activates Wnt/β‐catenin signalling to drive doxorubicin resistance in diffuse large B‐cell lymphoma
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.The high expression of PRMT7 enhances its interaction with DVL2 by methylating arginine residues on FOXK1/FOXK2. This process promotes the nuclear translocation of DVL2, thereby aberrantly activating the Wnt/β‐catenin signalling pathway, which ultimately drives the development of doxorubicin resistance in DLBCL.Xiaoyan Zhao, Jiasi Zhang, Yao Teng, Yaqin Wang, Wen Yu, Yan Sun, Zhou Wu, Aiguo Liu +7 morewiley +1 more sourceBevacizumab plus nab‐paclitaxel and platinum as second‐line therapy for driver‐gene‐negative non‐squamous non‐small cell lung cancer after immunochemotherapy: A prospective single‐arm single‐centre study
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.This study prospectively evaluated the efficacy and safety of the bevacizumab, nab‐paclitaxel and platinum combination as a second‐line therapy for driver‐gene‐negative advanced non‐squamous non‐small cell lung cancer after immunochemotherapy. The confirmed objective response rate was 46.4%.Ying Lin, Yunbo Yu, Zhihuang Hu, Chenchen Wei, Zezhou Wang, Yao Zhang, Zhenhua Wu, Bo Yu, Xinmin Zhao, Hui Yu, Xianghua Wu, Huijie Wang, Jialei Wang +12 morewiley +1 more source
