Results 81 to 90 of about 16,379 (217)

Extracranial, Extragonadal Germ Cell Tumors: A Multicenter Australian Case Series

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Extragonadal germ cell tumors (EGCTs) are rare, with limited prospective data to guide treatment or inform prognosis. Incidence and treatment patterns of EGCT in Australia reflect international data and practices. Compared to testicular primaries, the prognosis of EGCT is poor, especially for primary mediastinal non‐seminoma.
Kar Ven Cavan Chow, Ciara Conduit, Sophie O'Haire, Anna Kuchel, Shirley Wong, Peter Grimison, Andrew Weickhardt, Ganes Pranavan, James Lynam, Patricia Bastick, Jeffrey Goh, Shomik Sengupta, Annabel Smith, Elizabeth Liow, David Campbell, Ming Wong, Kristina Zlatic, Peter Gibbs, Ben Tran, Chun Loo Gan   +19 more
wiley   +1 more source

Targeting SPP1‐CD44‐Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis

Cancer Science, EarlyView.
SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka   +16 more
wiley   +1 more source

Independent prognostic significance of tumor budding and poorly differentiated clusters in Brazilian patients with stage II colorectal cancer

Surgical and Experimental Pathology
Background Colorectal cancer (CRC) is the third most commonly diagnosed and the second most fatal cancer worldwide. Tumor budding (TB) and poorly differentiated clusters (PDC) are morphological features with significant prognostic value that may aid ...
Monise Tadin Reis, Marcus Matsushita, Wellington Santos, Gustavo Noriz Berardinelli, Valiana Teodoro, Mariana Bisarro dos Reis, Denise Peixoto Guimarães, Rui Manuel Reis   +7 more
doaj   +1 more source

Interobserver variability of histopathological assessment in pT1 colorectal carcinoma

Histopathology, EarlyView.
Interobserver variability among 20 gastrointestinal pathologists was evaluated on 80 pT1 colorectal carcinoma cases. A pilot phase was followed by a consensus meeting, then a larger concordance study was performed. High interobserver agreement was achieved after consensus for histological grade, lymphovascular invasion, tumour budding, poorly ...
Karmele Saez de Gordoa, María Daca‐Alvarez, Maite Rodrigo‐Calvo, Ivan Archilla, Sandra Lopez‐Prades, Jose Javier Aguirre, Lorena Alarcón‐Molero, María Cámara Jurado, Adriana Canosa, Francisco Giner, Carmen González‐Lois, Mireya Jimeno, Ismael Jurado, Isidro Machado, Carolina Martínez‐Ciarpaglini, Eva Musulen, Dolores Naranjo, Natalia Papaleo, Cristina Peña, Òria Rosiñol, Rosario Sánchez‐Yuste, Greissy Tibisay Vázquez Benítez, María Pellisé, Miriam Cuatrecasas, on behalf of the EpiT1 Consortium   +24 more
wiley   +1 more source

In Memoriam: W. King Engel, MD (1930–2025)

Annals of Neurology, EarlyView.
Marinos C. Dalakas, Steven P. Ringel
wiley   +1 more source

Diagnosing Systemic Mastocytosis: State of the Art

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT With the advent of effective multikinase and selective tyrosine kinase inhibitors in systemic mastocytosis, diagnosing this rare disease has been critical to improving patient morbidity and mortality. This state‐of‐the‐art review interprets the international diagnostic criteria, including differences between the WHO 5th edition classification ...
Anton Rets, Tracy I. George
wiley   +1 more source

Molecular Alterations in Osteosarcomas of the Oral and Maxillofacial Region: A Scoping Review

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Given the rarity and aggressive nature of osteosarcomas (OS) in the oral and maxillofacial region, understanding their molecular alterations is essential to improve diagnosis, prognosis, and guide targeted therapies. This study aimed to map molecular alterations associated with oral and maxillofacial OS, providing an overview of the
Iara Vieira Ferreira, Reydson Alcides de Lima‐Souza, Moisés Willian Aparecido Gonçalves, Carlos Takahiro Chone, Arthur Antolini‐Tavares, Albina Altemani, Fernanda Viviane Mariano   +6 more
wiley   +1 more source

根治的前立腺全摘標本における神経線維周囲浸潤の生化学的再発予知因子としての意義 [PDF]

, 2005
著者らは, 臨床的限局性前立腺癌に対して術前内分泌療法を施行せずに根治的前立腺全摘除術を施行した202症例を対象に, 全摘標本における神経線維周囲浸潤の臨床病理学的意義を検討した.その結果, 1)神経線維周囲浸潤は131例(64.9%)に陽性であった.また, 神経線維周囲浸潤の存在は, 臨床病期, 病理学的病期, Gleasonスコア, 精嚢浸潤, リンパ節転移および腫瘍体積と有意に相関したが, 術前PSA値との相関は認めなかった.
Eto, Hiroshi, Hara, Isao, Harada, Ken-ichi, Miyake, Hideaki, Sakai, Iori   +4 more
core  

Clinicopathologic Analysis of Sarcomas in the Oral and Maxillofacial Region: A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to systematically review primary sarcomas in the oral and maxillofacial region, focusing on patient demographics and sarcoma‐specific characteristics, including clinical presentation, histopathology, treatment approaches, outcomes, and survival rates.
Iara Vieira Ferreira, Reydson Alcides de Lima‐Souza, Talita de Carvalho Kimura, Alfio José Tincani, Marcelo Elias Schempf Cattan, Arthur Antolini‐Tavares, Albina Altemani, Fernanda Viviane Mariano   +7 more
wiley   +1 more source

Volume Two Table of Contents [PDF]

, 1966
Table of contents for MCV/Q, Medical College of Virginia Quarterly, Volume ...

core   +1 more source