Results 31 to 40 of about 252,165 (283)

The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia. [PDF]

, 2017
The study of long noncoding RNAs (lncRNAs) is an emerging area of cancer research, in part due to their ability to serve as disease biomarkers. However, few studies have investigated lncRNAs in chronic lymphocytic leukemia (CLL).
Blachly, James S, Chen, Timothy L, Coombes, Kevin R, Flinn, Ian W, Fobare, Sydney, Grever, Michael R, Hertlein, Erin K, Kipps, Thomas J, Lehman, Amy, Liu, Chaomei, Lucas, David M, Miller, Cecelia R, Rassenti, Laura Z, Ruppert, Amy S, Sampath, Deepa, Tallman, Martin S, Zhang, Xiaoli   +16 more
core   +1 more source

repDilPCR: a tool for automated analysis of qPCR assays by the dilution-replicate method

BMC Bioinformatics
Background The dilution-replicate experimental design for qPCR assays is especially efficient. It is based on multiple linear regression of multiple 3-point standard curves that are derived from the experimental samples themselves and thus obviates the ...
Deyan Yordanov Yosifov, Michaela Reichenzeller, Stephan Stilgenbauer, Daniel Mertens   +3 more
doaj   +1 more source

V(D)J Recombination Excision Circles of B- and T-cells as Prognostic Marker in B-Cell Chronic Lymphocytic Leukemia

Клиническая онкогематология, 2017
Background & Aims. T-cell receptor excision circles (TREC) and κ-deleting recombination excision circles (KREC) are extrachromosomal DNA segments generated during V(D)J re combination process that characterize the diversity of the antigen repertoire of T-
Igor’ Vladimirovich Obraztsov, M. A. Gordukova, N. A. Severina, B. V. Biderman, S. Yu. Smirnova, A. B. Sudarikov, E. A. Nikitin, A. G. Rumyantsev   +7 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Genotyping from targeted NGS data based on a small set of SNPs correctly matches patient samples

BMC Research Notes
Objective Mislabelling and swapping of laboratory samples are handling errors that can lead to erroneous interpretation of data and/or patient harm.
Deyan Yordanov Yosifov, Christof Schneider, Stephan Stilgenbauer, Daniel Mertens, Eugen Tausch   +4 more
doaj   +1 more source

Targeting Bruton Tyrosine Kinase: A novel strategy in the treatment of B-cell lymphomas

Forum of Clinical Oncology, 2017
In normal B-cells, Bruton tyrosine kinase (Btk), a non-receptor tyrosine kinase involved in B-cell receptor (BCR) signalling, is essential for cell survival and maturation. Not surprisingly, Btk is also implicated in the pathogenesis of B-cell lymphomas,
Sklavenitis-Pistofidis R., Koletsa T., Lazaridou A., Goulas A.   +3 more
doaj   +1 more source

Paraneoplastic pemphigus - a rare autoimmune complication in patients with chronic lymphocytic leukemia

Онкогематология, 2022
This is a case report of the 64-year-old male patient who suffered of previously untreated chronic lymphocytic leukemia (CLL), and paraneoplastic pemphigus. He was treated with prednisolone, MabThera, chlorambucil and cyclophosphamide.
M. A. Volkova, M. Yu. Kitchigina, N. S. Potekaev, N. P. Teplyuk, A. G. Kupriyanova   +4 more
doaj   +1 more source

Targeting Brutons Tyrosine Kinase in Chronic Lymphocytic Leukemia at the Crossroad between Intrinsic and Extrinsic Pro-survival Signals [PDF]

, 2016
Chemo immunotherapies for chronic lymphocytic leukemia (CLL) showed a positive impact on clinical outcome, but many patients relapsed or become refractory to the available treatments.
Facco, Monica, Frezzato, Federica, Martini, Veronica, Semenzato, Gianpietro, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea   +7 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Effect of IGHV Gene Mutation Status and BCR Structure Stereotypy on Effectiveness of BR Regimen in First-Line Therapy of Chronic Lymphocytic Leukemia

Клиническая онкогематология, 2017
Background & Aims. The IGHV gene mutation status is a constant biological feature of tumor cells in chronic lymphocytic leukemia (CLL). This parameter is an important predictor of the efficacy of immunochemotherapy.
Vladimir Vladimirovich Strugov, E. A. Stadnik, A. M. Rumyantsev, T. O. Andreeva, Yu. V. Virts, Yu. V. Mirolyubova, P. A. Butylin, A. Yu. Zaritskey   +7 more
doaj   +1 more source