Results 41 to 50 of about 252,165 (283)

Advocating the need of a systems biology approach for personalised prognosis and treatment of B-CLL patients [PDF]

, 2012
The clinical course of B-CLL is heterogeneous. This heterogeneity leads to a clinical dilemma: can we identify those patients who will benefit from early treatment and predict the survival?
Goltsov, Alexey, Khalil, Hilal S., Mitev, Vanio, Scott, Fiona, Sproul, Anne, Tummala, Hemanth, Zhelev, Nikolai   +6 more
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Role of Patient’s Age and Comorbidities in Therapy of Chronic Lymphocytic Leukemia

Клиническая онкогематология, 2016
Background & Aims. New schemes of the antitumor therapy of CLL resulted in improvement of survival of relatively young patients. However, the therapy outcomes of elderly patients are still unsatisfactory.
Vladimir Vladimirovich Strugov, E. A. Stadnik, Yu. V. Virts, T. O. Silina, A. Yu. Zaritskii   +4 more
doaj   +1 more source

Auer Rod-Like Inclusions in Chronic Lymphocytic Leukemia: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Auer rod‐like inclusions may occasionally be observed in chronic lymphocytic leukemia. Their recognition on peripheral smear highlights the importance of meticulous morphology assessment when comprehensive hematologic testing cannot be performed.
Zhang T, Xie L.
europepmc   +2 more sources

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. [PDF]

, 2004
We studied the actions of geldanamycin (GA) and herbimycin A (HMA), inhibitors of the chaperone proteins Hsp90 and GRP94, on B chronic lymphocytic leukemia (CLL) cells in vitro.
Addison, E, Folarin, NI, Ganeshaguru, K, Hoffbrand, AV, Jones, DT, Lowdell, MW, Mehta, AB, North, JM, Wickremasinghe, RG   +8 more
core   +1 more source

Integrated Ultrasound Device for Precision Bladder Volume Monitoring via Acoustic Focusing and Machine Learning

Advanced Science, EarlyView.
We present a conformable wearable ultrasound patch for noninvasive bladder volume monitoring. A flexible PZT array combined with a concave acoustic lens concentrates acoustic energy and improves depth selectivity through the anterior pelvic wall.
Long Long Cao, Feng Wen Wang, Jingwei Xue, Fulei Liu, Ming Liang Jin   +4 more
wiley   +1 more source

COVID-19-Induced Hyperleucocytosis in Chronic Lymphocytic Leukaemia

European Journal of Case Reports in Internal Medicine, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus responsible for the current global pandemic, coronavirus disease 2019 (COVID-19).
Balraj Singh, Sarah Ayad, Parminder Kaur, Ro-Jay Reid, Sachin Gupta, Michael Maroules   +5 more
doaj   +1 more source

A rare case of appendicular skeleton localization in a patient with chronic lymphocytic leukemia successfully treated with salvage radiation therapy [PDF]

, 2017
Bone involvements in chronic lymphocytic leukemia (CLL) are considered rare events, and the English-language medical literature describes them only in sporadic case reports. Consequently, robust indications for a rational clinical management are lacking.
Al Sayyad, Said, Arico, Demetrio, Di Cristofano, Claudio, Marchione, Anna Maria, Petrozza, Vincenzo, Porta, Natale, Ronco, Francesca, Russi, Elvio Grazioso, Sceni, Giuseppe, Stelitano, Caterina, Tuscano, Carmelo, Versace, Paolo, Vincelli, Iolanda Donatella   +12 more
core   +1 more source

2026 Update on the Management of Diffuse Large B‐Cell Lymphoma

American Journal of Hematology, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong, Emily B. Tomasulo, Stefan K. Barta   +2 more
wiley   +1 more source