Results 31 to 40 of about 242,018 (254)

repDilPCR: a tool for automated analysis of qPCR assays by the dilution-replicate method

BMC Bioinformatics
Background The dilution-replicate experimental design for qPCR assays is especially efficient. It is based on multiple linear regression of multiple 3-point standard curves that are derived from the experimental samples themselves and thus obviates the ...
Deyan Yordanov Yosifov, Michaela Reichenzeller, Stephan Stilgenbauer, Daniel Mertens   +3 more
doaj   +1 more source

TSPAN5: A Potential Biomarker for Methotrexate Resistance in Acute Lymphoblastic Leukemia in Iraq [PDF]

Journal of Bioscience and Applied Research
The transmembrane receptor family known as tetraspanins (TSPANs) was integral to diverse cellular processes, including protein anchoring, scaffolding, and signal transduction.
Muslim Mohsin, Muneer Khudhair
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Genotyping from targeted NGS data based on a small set of SNPs correctly matches patient samples

BMC Research Notes
Objective Mislabelling and swapping of laboratory samples are handling errors that can lead to erroneous interpretation of data and/or patient harm.
Deyan Yordanov Yosifov, Christof Schneider, Stephan Stilgenbauer, Daniel Mertens, Eugen Tausch   +4 more
doaj   +1 more source

Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia

Hematology/Oncology and Stem Cell Therapy, 2019
Objective/Background: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune ...
Eman Mosaad Zaki, Asmaa Mohamed Zahran, Alshimaa Abdelazeem Metwaly, Rania Hafez, Safinaz Hussein, Abdallah Elaiw Mohammed   +5 more
doaj   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Targeting Bruton Tyrosine Kinase: A novel strategy in the treatment of B-cell lymphomas

Forum of Clinical Oncology, 2017
In normal B-cells, Bruton tyrosine kinase (Btk), a non-receptor tyrosine kinase involved in B-cell receptor (BCR) signalling, is essential for cell survival and maturation. Not surprisingly, Btk is also implicated in the pathogenesis of B-cell lymphomas,
Sklavenitis-Pistofidis R., Koletsa T., Lazaridou A., Goulas A.   +3 more
doaj   +1 more source

V(D)J Recombination Excision Circles of B- and T-cells as Prognostic Marker in B-Cell Chronic Lymphocytic Leukemia

Клиническая онкогематология, 2017
Background & Aims. T-cell receptor excision circles (TREC) and κ-deleting recombination excision circles (KREC) are extrachromosomal DNA segments generated during V(D)J re combination process that characterize the diversity of the antigen repertoire of T-
Igor’ Vladimirovich Obraztsov, M. A. Gordukova, N. A. Severina, B. V. Biderman, S. Yu. Smirnova, A. B. Sudarikov, E. A. Nikitin, A. G. Rumyantsev   +7 more
doaj   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects [PDF]

, 2017
A growing body of studies highlights involvement of neutrophils in cancer development and progression. Our aim was to assess the phenotypic and functional properties of circulating neutrophils from patients with chronic lymphocytic leukemia (CLL).
Gabčová, Gabriela, Gajdoš, Petr, Kriegová, Eva, Kudělka, Miloš, Manukyan, Gayane, Mikulková, Zuzana, Papajík, Tomáš, Procházka, Vít, Ryznerová, Pavlína, Turcsányi, Peter, Urbanová, Renata   +10 more
core   +1 more source