Results 31 to 40 of about 88,264 (269)

repDilPCR: a tool for automated analysis of qPCR assays by the dilution-replicate method

BMC Bioinformatics
Background The dilution-replicate experimental design for qPCR assays is especially efficient. It is based on multiple linear regression of multiple 3-point standard curves that are derived from the experimental samples themselves and thus obviates the ...
Deyan Yordanov Yosifov, Michaela Reichenzeller, Stephan Stilgenbauer, Daniel Mertens   +3 more
doaj   +1 more source

Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL [PDF]

Blood, 2017
Key Points Pembrolizumab was first shown to be clinically active in CLL patients with RT. PD-1 and PD-L1 expression in tumor microenvironment are promising biomarkers to select RT patients for PD-1 blockade.
Wei, Ding, Betsy R, LaPlant, Timothy G, Call, Sameer A, Parikh, Jose F, Leis, Rong, He, Tait D, Shanafelt, Sutapa, Sinha, Jennifer, Le-Rademacher, Andrew L, Feldman, Thomas M, Habermann, Thomas E, Witzig, Gregory A, Wiseman, Yi, Lin, Erik, Asmus, Grzegorz S, Nowakowski, Michael J, Conte, Deborah A, Bowen, Casey N, Aitken, Daniel L, Van Dyke, Patricia T, Greipp, Xin, Liu, Xiaosheng, Wu, Henan, Zhang, Charla R, Secreto, Shulan, Tian, Esteban, Braggio, Linda E, Wellik, Ivana, Micallef, David S, Viswanatha, Huihuang, Yan, Asher A, Chanan-Khan, Neil E, Kay, Haidong, Dong, Stephen M, Ansell   +34 more
openaire   +2 more sources

sj-docx-1-cll-10.1177_09636897221078026 – Supplemental material for Knockdown of the Long Noncoding RNA TUG1 Suppresses Retinoblastoma Progression by Disrupting the Epithelial–Mesenchymal Transition

, 2022
Supplemental material, sj-docx-1-cll-10.1177_09636897221078026 for Knockdown of the Long Noncoding RNA TUG1 Suppresses Retinoblastoma Progression by Disrupting the Epithelial–Mesenchymal Transition by Hongyi Wang, Zhen Zhang, Yue Zhang and Li Li in Cell ...
Hongyi Wang (2427745), Yue Zhang (30585), Li Li (14993), Zhen Zhang (86004)   +3 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Genotyping from targeted NGS data based on a small set of SNPs correctly matches patient samples

BMC Research Notes
Objective Mislabelling and swapping of laboratory samples are handling errors that can lead to erroneous interpretation of data and/or patient harm.
Deyan Yordanov Yosifov, Christof Schneider, Stephan Stilgenbauer, Daniel Mertens, Eugen Tausch   +4 more
doaj   +1 more source

The Role of BTK Inhibition in the Treatment of Chronic Lymphocytic Leukemia: A Clinical View

Journal of Experimental Pharmacology, 2021
Francesco Paolo Tambaro,1 Danilo De Novellis,1,2 William G Wierda3 1Unità Operativa di Trapianto di Midollo Osseo e Servizio Trasfusionale, Azienda Ospedaliera di Rilievo Nazionale Santobono-Pausilipon, Napoli, Italy; 2Department of Precision Medicine ...
Tambaro FP, De Novellis D, Wierda WG
doaj  

Ibrutinib plus Obinutuzumab as Frontline Therapy for Chronic Lymphocytic Leukemia Is Associated with a Lower Rate of Infusion-Related Reactions and with Sustained Remissions after Ibrutinib Discontinuation: A Single-Arm, Open-Label, Phase 1b/2 Clinical Trial NCT0231576

Advances in Hematology, 2022
Ibrutinib-based therapies are costly and require continuous administration. We hypothesized combining BTK inhibition with anti-CD20 monoclonal antibodies would yield deep remissions allowing discontinuation.
Januario E. Castro, Paula A. Lengerke-Diaz, Juliana Velez Lujan, Michael Y. Choi, Eider F. Moreno-Cortes, Jose V. Forero, Juan Esteban Garcia-Robledo, Chaja Jacobs, Colin McCarthy, Alaina Heinen, Carlos I. Amaya-Chanaga, Thomas J. Kipps   +11 more
doaj   +1 more source

sj-jpg-1-cll-10.1177_09636897221145682 – Supplemental material for Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia

, 2023
Supplemental material, sj-jpg-1-cll-10.1177_09636897221145682 for Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia by Hongyu Liu, Ling Yu, Yiling Ding, Mei Peng and Yali Deng in Cell
Hongyu Liu (103192), Yali Deng (829824), Yiling Ding (552383), Ling Yu (330944), Mei Peng (729927)   +4 more
core   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12 [PDF]

, 2012
Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling ...
McCaig, Alison M., Alison M McCaig, Alison M. Mccaig, Cosimo Emilio, Alison M. Michie, Leach Michael T., Alison M Michie, Emilio Cosimo, Michael T. Leach, McCaig Alison M., Michael T Leach, Michie, Alison M., Michie Alison M., Cosimo, Emilio, Leach, Michael T.   +14 more
core   +1 more source