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A CLOCK-less clock

Trends in Cell Biology, 2006
Mammalian physiology is governed by a complex circadian timing system that involves interacting positive and negative transcriptional feedback loops. A key role in this feedback loop was attributed to the PAS domain helix-loop-helix protein CLOCK, on the basis of a dominant-negative mutation in this transcription factor.
Asher, Gad, Schibler, Ulrich
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Clocked Cell Cycle Clocks

Science, 1981
The cell division cycle of both mammalian cells and microorganisms, which apparently has both deterministic and probabilistic features, is a clock of sorts in that the sequence of events that comprise it measures time under a given set of environmental conditions.
Leland N. Edmunds, Kenneth J. Adams
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Atomic clock performance enabling geodesy below the centimetre level

Nature, 2018
The passage of time is tracked by counting oscillations of a frequency reference, such as Earth’s revolutions or swings of a pendulum. By referencing atomic transitions, frequency (and thus time) can be measured more precisely than any other physical ...
W. McGrew   +22 more
semanticscholar   +1 more source

Circadian clocks: Not your grandfather’s clock

Science, 2016
The last 20 years have seen the rapid evolution of our understanding of the molecular genes and networks that enable almost all forms of life to generate 24-hour—or circadian—rhythms. One finding has been particularly exciting: that the molecular circadian clock resides in almost all of the cells of the body and that the clock regulates the timing of ...
Fred W. Turek, Fred W. Turek
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Melatonin: A Clock‐Output, A Clock‐Input

Journal of Neuroendocrinology, 2003
AbstractIn mammals, the circadian system is comprised of three major components: the lateral eyes, the hypothalamic suprachiasmatic nucleus (SCN) and the pineal gland. The SCN harbours the endogenous oscillator that is entrained every day to the ambient lighting conditions via retinal input.
C. von Gall   +2 more
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Role of the CLOCK protein in the mammalian circadian mechanism.

Science, 1998
The mouse Clock gene encodes a bHLH-PAS protein that regulates circadian rhythms and is related to transcription factors that act as heterodimers. Potential partners of CLOCK were isolated in a two-hybrid screen, and one, BMAL1, was coexpressed with ...
N. Gekakis   +7 more
semanticscholar   +1 more source

By the Clock [PDF]

open access: possibleReviews in American History, 2000
In his first book, Ian R. Bartky examines the history of American observatories during the nineteenth century in order to "assess the significance of time services in the development of American astronomy" (p. 3). He shows that time services provided some of the revenue and much of the raison d'etre for many fledgling observatories.
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Last clock

IEEE Computer Graphics and Applications, 2005
The Last clock displays a space's history and rhythm. Trails behind its hands paint the clock face with a video feed, creating a mandala of archived time. The Last clock began as an investigation into representations of time. The goal was to use the mutable properties of digital technology, hoping to create something aesthetically pleasing, interesting,
Ross Cooper, Jussi Ängeslevä
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