Results 31 to 40 of about 1,086,533 (280)

Clinical and genetic associations of the CLOCK circadian rhythm gene and depressive disorders in patients with alcohol dependence syndrome during the period of alcohol abstinence

open access: yesНеврология, нейропсихиатрия, психосоматика, 2022
About 20% of patients with depression are diagnosed with alcohol dependence, and alcohol dependent individuals are at a higher risk of developing depression.
N. R. Tulbaeva   +7 more
doaj   +1 more source

Molecular clocks [PDF]

open access: yesCurrent Biology, 2016
In the 1960s, several groups of scientists, including Emile Zuckerkandl and Linus Pauling, had noted that proteins experience amino acid replacements at a surprisingly consistent rate across very different species. This presumed single, uniform rate of genetic evolution was subsequently described using the term 'molecular clock'.
Michael S Y, Lee, Simon Y W, Ho
openaire   +2 more sources

Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis

open access: yesScientific Reports, 2017
We recently found that the mRNA expression of Slc25a25, a Ca2+-sensitive ATP carrier in the inner mitochondrial membrane, fluctuates in a circadian manner in mouse skeletal muscle.
Reiko Nakao   +2 more
doaj   +1 more source

A whole lifespan mouse multi-tissue DNA methylation clock

open access: yeseLife, 2018
Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks, have been developed for humans and extended to several other species.
Margarita V Meer   +3 more
doaj   +1 more source

REVIEW OF RESEARCH ON THE RELATIONSHIP BETWEEN CIRCADIAN RHYTHMS AND CARCINOGENESIS USING ANIMAL MODELS

open access: yesСибирский онкологический журнал, 2021
Purpose of the study: to review in vivo studies on the relationship and role of various molecular genetic components of the circadian rhythm system in the initiation and development of malignant neoplasms.
G. S. Kireeva   +8 more
doaj   +1 more source

A bioinformatic analysis identifies circadian expression of splicing factors and time-dependent alternative splicing events in the HD-MY-Z cell line [PDF]

open access: yes, 2019
The circadian clock regulates key cellular processes and its dysregulation is associated to several pathologies including cancer. Although the transcriptional regulation of gene expression by the clock machinery is well described, the role of the clock ...
Abreu, Mónica   +4 more
core   +1 more source

Biological clocks [PDF]

open access: yesProceedings of the National Academy of Sciences, 1999
Circadian rhythms describe biological phenomena that oscillate with an ≈24-hour cycle. These rhythms include blood pressure, body temperature, hormone levels, the number of immune cells in blood, and the sleep-wake cycle. In this paper, we will focus on common genes between species that are responsible for determining the circadian behavior ...
N, Ishida, M, Kaneko, R, Allada
openaire   +2 more sources

FUNCTIONAL IMPLICATIONS OF THE CLOCK 3111T/C SINGLE-NUCLEOTIDE POLYMORPHISM

open access: yesFrontiers in Psychiatry, 2016
Circadian rhythm disruptions are prominently associated with Bipolar Disorder (BD). Circadian rhythms are regulated by the molecular clock, a family of proteins that function together in a transcriptional-translational feedback loop. The CLOCK protein is
Angela Renee Ozburn   +8 more
doaj   +1 more source

Compensation Method for Sensor Network Clock Error Based on Cyclic Symmetry Algorithm

open access: yesSensors, 2020
Since the existing methods cannot evaluate the time delay of different layers of sensor networks, there are some problems such as the low precision of clock error compensation, high time delay, and low efficiency of communication in sensor networks.
Hailiang Feng   +3 more
doaj   +1 more source

Rodent models for the analysis of tissue clock function in metabolic rhythms research [PDF]

open access: yes, 2017
The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level.
Astiz, Mariana   +3 more
core   +2 more sources

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