Results 61 to 70 of about 1,354,268 (327)

Frequency ratios of Sr, Yb and Hg based optical lattice clocks and their applications [PDF]

, 2015
This article describes the recent progress of optical lattice clocks with neutral strontium ($^{87}$Sr), ytterbium ($^{171}$Yb) and mercury ($^{199}$Hg) atoms.
Akatsuka, Tomoya, Das, Manoj, Katori, Hidetoshi, Nemitz, Nils, Ohkubo, Takuya, Ohmae, Noriaki, Takamoto, Masao, Takano, Tetsushi, Ushijima, Ichiro, Yamaguchi, Atsushi, Yamanaka, Kazuhiro   +10 more
core   +2 more sources

Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism.

Journal of Molecular Endocrinology, 2018
The mammalian circadian clock has evolved as an adaptation to the 24-hour light/dark cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism (such as eating and sleeping) helps different tissue and organ systems ...
K. H. Cox, J. Takahashi
semanticscholar   +1 more source

The hepatocyte clock and feeding control chronophysiology of multiple liver cell types

Science, 2020
The hepatocyte clock and food availability control gene expression and metabolism in nonhepatocytic cells in the liver. Keeping rhythm requires communication In mammals, daily cycles in physiology require the synchronized activity of circadian clocks in ...
D. Guan, Ying Xiong, T. M. Trinh, Yang Xiao, Wenxiang Hu, Chunjie Jiang, Pieterjan Dierickx, Cholsoon Jang, J. Rabinowitz, M. Lazar   +9 more
semanticscholar   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

A balance of positive and negative regulators determines the pace of the segmentation clock

eLife, 2015
Somitogenesis is regulated by a molecular oscillator that drives dynamic gene expression within the pre-somitic mesoderm. Previous mathematical models of the somitogenesis clock that invoke the mechanism of delayed negative feedback predict that its ...
Guy Wiedermann, Robert Alexander Bone, Joana Clara Silva, Mia Bjorklund, Philip J Murray, J Kim Dale   +5 more
doaj   +1 more source

Differential Effect of Fructose in the Presence or Absence of Fatty Acids on Circadian Metabolism in Hepatocytes

Metabolites, 2023
We aimed to explore whether fructose in the absence or presence of fatty acids modulates circadian metabolism in AML-12 hepatocytes. Fructose treatment under steatosis conditions (FruFA) led to fat synthesis resulting in increased triglycerides and ...
Shani Tsameret, Nava Chapnik, Oren Froy
doaj   +1 more source

Alternative Splicing of Circadian Clock Genes Correlates With Temperature in Field-Grown Sugarcane [PDF]

, 2019
Alternative Splicing (AS) is a mechanism that generates different mature transcripts from precursor mRNAs (pre-mRNAs) of the same gene. In plants, a wide range of physiological and metabolic events are related to AS, as well as fast responses to changes ...
Alabadí, Amorim, Annunziata, Annunziata, Beyer, Bieniawska, Calixto, Calixto, Calixto, Calixto, Chamala, Chan, Chaudhary, Cuadrado, Dantas, de Setta, Ding, Dodd, Dodd, D’Hont, D’Hont, Endo, Filichkin, Filichkin, Filichkin, Filichkin, Fouquet, Frank, Fung-Uceda, Garcia, Garsmeur, Godoy Herz, Graf, Graf, Graveley, Grundy, Göhring, Harmer, Haydon, Higashi, Hotta, Hsu, Iskandar, Izawa, Izawa, Jabre, Jacob, James, James, James, Jones, Kalyna, Khan, Ko, Kornblihtt, Kriechbaumer, Kwon, Lai, Liu, Locke, Lu, Marquez, Marshall, Mastrangelo, McClung, McCormick, Millar, Miller, Min, Moll, Moore, Murakami, Nagano, Nagashima, Nakamichi, Ng, Ni, Oesterreich, Palusa, Para, Park, Pokhilko, Reddy, Remy, Riaño-Pachón, Richards, Rosloski, Saldi, Sato, Seo, Seo, Severing, Shalit-Kaneh, Shang, Shen, Simpson, Simpson, Souza, Staiger, Staiger, Sugliani, Syed, Szakonyi, Thatcher, Vaneechoutte, Vicentini, Wang, Zeilinger, Zhang, Zhang, Zhang, Zhang   +111 more
core   +2 more sources

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock.

Cancer Discovery, 2019
Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells (GSCs). Here, we show that GSCs, differentiated glioblastoma cells (DGCs), and non-malignant brain cultures all displayed robust circadian rhythms, yet GSCs alone ...
Zhen Dong, Guoxin Zhang, Meng Qu, Ryan C. Gimple, Qiulian Wu, Zhixin Qiu, B. Prager, Xiuxing Wang, Leo J. Y. Kim, Andrew R. Morton, Deobrat Dixit, Wenchao Zhou, Haidong Huang, B. Li, Zhe Zhu, S. Bao, S. Mack, L. Chavez, S. Kay, J. Rich   +19 more
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Marine-Derived Bioactive Ingredients in Functional Foods for Aging: Nutritional and Therapeutic Perspectives

Marine Drugs
Aging is closely linked to various health challenges, including cardiovascular disease, metabolic disorders, and neurodegenerative conditions.
Youngji Han, Dong Hyun Kim, Seung Pil Pack   +2 more
doaj   +1 more source