Results 101 to 110 of about 108,470 (277)
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Langevin equation approach to granular flows in narrow pipes
, 1998 The flow of granular material through a rough narrow pipe is described by the Langevin equation formalism. The stochastic force is caused by irregular interaction between the wall and the granular particles.
Dirk Rosenkranz +4 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Experimental study on influence of soil particle size distribution on clogging in recharge wells
Yantu gongcheng xuebaoLong-term operation of recharge wells leads to progressive decline in recharge efficiency, that is, the phenomenon of well clogging. As the most critical factor constraining recharge technology application, the mechanisms underlying recharge well ...
SUN Junyuan 1, ZHOU Shilong 2, LUO Jiugang 3, CUI Min 3, CHENG Xuesong 2, LI Qinghan 2
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Energy Science & EngineeringFormation clogging in carbonate gas reservoirs is a significant challenge in natural gas extraction, particularly due to the complex mineral composition and physicochemical characteristics of carbonate rocks, which make clogging phenomena even more ...
Jin Pang +5 more
doaj +1 more source
BrodogradnjaFilter clogging is a critical issue in ballast-water management systems (BWMSs) and is caused by the accumulation of sediment deposits and particles in water, particularly under high total suspended solid (TSS) conditions.
Gang Nam Lee +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source