Results 81 to 90 of about 25,387 (261)

Multidimensional Characterization of Formation Damage Mechanisms in Ancient Carbonate Reservoirs: Synergistic Effects of Inorganic‐Organic Interactions

Energy Science & Engineering
Formation clogging in carbonate gas reservoirs is a significant challenge in natural gas extraction, particularly due to the complex mineral composition and physicochemical characteristics of carbonate rocks, which make clogging phenomena even more ...
Jin Pang, Tongtong Wu, Xinan Yu, Hong Liu, Chunxi Zhou, Haotian Chen   +5 more
doaj   +1 more source

Experimental study on influence of soil particle size distribution on clogging in recharge wells

Yantu gongcheng xuebao
Long-term operation of recharge wells leads to progressive decline in recharge efficiency, that is, the phenomenon of well clogging. As the most critical factor constraining recharge technology application, the mechanisms underlying recharge well ...
SUN Junyuan 1, ZHOU Shilong 2, LUO Jiugang 3, CUI Min 3, CHENG Xuesong 2, LI Qinghan 2
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

A feasible method for the composition analysis and chemical remediation of clogging matter in subsurface flow constructed wetlands

Water Cycle
The problem of clogging, especially biological clogging, makes the long-term operation of subsurface flow constructed wetlands challenging. This study focused on the two subsurface flow constructed wetlands receiving reclaimed water near the Tuhai River ...
Yu Zheng, Yuyang Song, Rongshe Zhang, Nan Zhang, Mohomed Salah, Siyi Cheng, Yuanyuan Li, Qian Wang, Chenguang Li, Fengmin Li   +9 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Mathematical Modeling of Transient Submerged Entry Nozzle Clogging and Its Effect on Flow Field, Bubble Distribution and Interface Fluctuation in Slab Continuous Casting Mold

Metals
Submerged entry nozzle (SEN) clogging will affect the production efficiency and product quality in the continuous casting process. In this work, the transient SEN clogging model is developed by coupling the porous media model defined by the user-defined ...
Yuntong Li, Wenyuan He, Changliang Zhao, Jianqiu Liu, Zeyu Yang, Yuhang Zhao, Jian Yang   +6 more
doaj   +1 more source