Results 111 to 120 of about 139,098 (277)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

A meta-analysis of labyrinth channel emitter clogging characteristics under Yellow River water drip tape irrigation

Agricultural Water Management
Emitter clogging restricts the promotion and application of drip irrigation technology for Yellow River water. The influence degree of water quality, flow path structure, and operation time on emitter clogging varies.
Chang Lv, Wenquan Niu, Yadan Du, Jun Sun, Aihong Dong, Menglong Wu, Fei Mu, Jinjin Zhu, Kadambot H.M. Siddique   +8 more
doaj   +1 more source

Keberkesanan pengaplikasian e-modul semiconductor devices menggunakan augmented reality bagi Pelajar Kejuruteraan Elektronik di Politeknik Merlimau, Melaka [PDF]

, 2018
Augmented Reality (AR) kini digunakan secara meluas dalam kehidupan seharian, salah satunya adalah dalam bidang pendidikan. Pada masa kini, aplikasi AR dapat diintegrasikan untuk meningkatkan standard kurikulum yang digunakan, seperti teks, grafik, video,
Johar, Siti Hajar
core  

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Математическое моделирование процесса разделения суспензии на фильтре с самоочищающимся фильтрующим элементом [PDF]

, 2016
Математична модель може бути застосована при розрахунку параметрів процесу фільтрування суспензії на фільтрі із самоочисним фільтрувальним елементом.Отримана математична модель ґрунтується на моделі процесу фільтрування із закупорюванням кожної пори ...
Кравець, Олег Ігорович, Шинкарик, Марія Миколаївна   +1 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Experimental study on influence of soil particle size distribution on clogging in recharge wells

Yantu gongcheng xuebao
Long-term operation of recharge wells leads to progressive decline in recharge efficiency, that is, the phenomenon of well clogging. As the most critical factor constraining recharge technology application, the mechanisms underlying recharge well ...
SUN Junyuan 1, ZHOU Shilong 2, LUO Jiugang 3, CUI Min 3, CHENG Xuesong 2, LI Qinghan 2
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Study on filter clogging and filtration performance evaluation of Ballast Water Management System (BWMS) using analytical and numerical methods

Brodogradnja
Filter clogging is a critical issue in ballast-water management systems (BWMSs) and is caused by the accumulation of sediment deposits and particles in water, particularly under high total suspended solid (TSS) conditions.
Gang Nam Lee, Tien Trung Duong, Sangho Park, Mansoo Kim, Kwang Hyo Jung   +4 more
doaj   +1 more source