Results 131 to 140 of about 5,946 (255)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

[From cutaneous abscess to ventriculitis caused by Panton-Valentine leukocidin-positive methicillin-resistant <i>Staphylococcus aureus</i>]. [PDF]

Rev Esp Quimioter
Pintor-Rey M, Carrasco-González A, Lejarraga-Cañas C, Gutierrez-Rico R, Mateos-Goñi B, Guío-Carrión L.   +5 more
europepmc   +1 more source

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. [PDF]

Sci Transl Med, 2021
Fan Y, Teng Y, Loison F, Pang A, Kasorn A, Shao X, Zhang C, Ren Q, Yu H, Zheng Y, Cancelas JA, Manis J, Chai L, Park SY, Zhao L, Zhao L, Xu Y, Feng S, Silberstein LE, Ma F, Luo HR.   +20 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Analysis of Morphological High-Risk Factors for Retrograde Type A Aortic Dissection. [PDF]

Rev Cardiovasc Med
Long C, Xia J, Luo C, Cai J, Khan A, Feng Y, Lei Z.   +6 more
europepmc   +1 more source

Clonidine for the Treatment of Agitation After Dexmedetomidine Discontinuation in Pediatric Patients: A Retrospective Cohort Study. [PDF]

J Pediatr Pharmacol Ther, 2021
Nguyen TL, Lam WM, Orr H, Gulbis B, Mauricio R, Tom E, Modem VM, Coronado-Munoz A.   +7 more
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Alpha-2 Adrenergic Agonists Reduce Heavy Alcohol Drinking and Improve Cognitive Performance in Mice. [PDF]

eNeuro
Quadir SG, Lepeak L, Miracle S, Collu R, Velte O, He Y, Ozturk Z, Rohl CD, Sabino V, Cottone P.   +9 more
europepmc   +1 more source

Qualitative and Quantitative Analysis of Secondary Metabolites in Morphological Parts of Paulownia Clon In Vitro 112^® and Their Anticoagulant Properties in Whole Human Blood. [PDF]

Molecules, 2022
Stochmal A, Moniuszko-Szajwaj B, Zuchowski J, Pecio Ł, Kontek B, Szumacher-Strabel M, Olas B, Cieslak A.   +7 more
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source