Results 71 to 80 of about 5,946 (255)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Rendimiento en la yuca (manihot esculenta) en diferentes arreglos espaciales

Agronomía Costarricense, 2004
En los años 1993 y 1994, fueron desarrollados experimentos de campo en el Instituto Nacional de Ciencias Agrícolas, San José de las Lajas, La Habana, Cuba.
Modesto Mojena, Martín Pascual Bertolí
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Modal Extensions of CLoN with Bi-neighborhood Semantics

In this paper we will present neighborhood semantics for non-normal modal extensions of $\clon$, which is a sublogic of {\sf FDE}. Our framework is built upon earlier work on {\sf FDE}-based non-normal modal logics and employs two different neighborhood functions for each modal operator. Despite being a logic with a very weak negation operator, we will
Vaz, Mahan, Skurt, Daniel
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Contenido de materia seca y almidón en clones de yuca (Manihot esculenta Crantz)

Revista Biológico Agropecuaria Tuxpan, 2014
El objetivo del trabajo fue determinar el contenido de materia seca y almidón en ocho clones de yuca colectados en el estado de Veracruz. Para calcular la materia seca de la raíz, a partir del rendimiento de raíces frescas, se utilizó el método de la ...
Isaac Meneses Márquez, Andrés Vásquez Hernández, Xóchitl Rosas González, Enrique Noé Becerra Leor   +3 more
doaj   +1 more source

El conocimiento prohibido y el clon humano

Forseti: Revista de Derecho, 2016
By means of this paper, Gerardo Eto Cruz analyzes the controversies that generated the discovery regarding to human's genomes and the posibilites that these represents, such as human cloning. Likewise, he questions himself if the aspects related to the biology and biotechnology should be regulated, taking into account theological and rational arguments,
openaire   +3 more sources

Producción de ñame clon Criollo a partir de bulbillos aéreos

Agronomía Mesoamericana, 2018
The employment of air bulbils in yam plants, like plantation material, allows using a 100% of the tubers crop for its consumption, the aforementioned implicates a significant agronomic, economic, social, and environmental impact. The aim of this study was to evaluate the main morphological and agronomic indicators of Creole clone yam in vitro plants ...
Borges-García, Misterbino, Reyes-Avalos, Diana María, Leyva-Domínguez, Humberto, Ávila-Medina, Ubail, Lambert-García, Tania   +4 more
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source