Results 81 to 90 of about 4,828 (201)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

CAERI 4, nueva variedad de cacao para las áreas cacaoteras de México

Ecosistemas y Recursos Agropecuarios
El clon de cacao CAERI 4 proviene de la cruza de los clones Baalam x CATIE R6 realizada en el Campo Experimental Rosario Izapa del INIFAP, y evaluado en tres ambientes (Tuxtla chico y Umoa, Chiapas y Teapa, Tabasco) donde mostró estabilidad en la ...
Carlos Hugo Avendaño-Arrazate, Misael Martínez-Bolaños, Leobardo Iracheta-Donjuan   +2 more
doaj   +1 more source

Comparación agronómica y cualitativa de 3 clones preseleccionados de la variedad tinta Bruñal, en Valladolid (España), en el periodo 2015–2016

BIO Web of Conferences, 2019
La variedad de vid tinta Bruñal está localizada mayoritariamente en la Denominación de Origen (D.O.) Arribes, ubicada en las provincias de Zamora y Salamanca.
Yuste J., Vicente A., Barajas E., Rubio J.A., Martínez-Porro D.   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Metamorfosis digital: un fenómeno llamado Clon

, 2019
Clon. Cyberzine de Arte y Cultura es un proyecto de la Universidad Autónoma Metropolitana de Xochimilco, que nace en 1997 con el fin de investigar el uso que se le puede dar a las Tecnologías de Información y Comunicación (TIC) en la creación y difusión ...
Pérez Reyes, Eduardo, Rivero Herrera, Antonio del   +1 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Динамика содержания гиббереллина А3 в Tradescantia (clon 02) после острого γ-облучения в малой дозе

, 2019
Была изучена динамика содержания гиббереллина А3 после острого γ-облучения в дозе 6.0 сГр в соцветиях Tradescantia (clon 02). Показано, что на протяжении 5 ч после облучения наблюдалось увеличение содержания гиббереллина, достигавшее более чем ...
Хомиченко А.А., Скоробогатова И.В.   +1 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Respuesta del banano (clon «gran enano») a la fertirrigación con diferentes fuentes potásicas en ciénaga (magdalena) [PDF]

, 1996
En un sistema de fertirrigación (por goteo) se efectuó un experimento para evaluar la eficiencia agronómica y económica de dos fertilizantes potásicos (KN03 y K2S04) y su mezcla en el cultivo del banano (Clon «Gran Enano», 3ª. cepa).
Ospina Aguirre, Juan, Guerrero Riascos, Ricardo, Reyes, Jorge Gadbán   +2 more
core