Results 171 to 180 of about 3,725,865 (331)

Advancing SafeWax, A Bio‐Inspired Superhydrophobic Coating, Toward Sustainable and Climate‐Resilient Crop Protection

open access: yesAdvanced Functional Materials, EarlyView.
This study advances SafeWax, a bio‐inspired, fatty‐acids‐based superhydrophobic coating, by identifying an agriculturally compliant solvent and revealing how solvent‐controlled Fatty acid crystallization governs the coating's microscopic structure and performance.
Niv Ben‐Arie   +13 more
wiley   +1 more source

Rapid clonal expansion and adaptation from standing genetic variation underpin the evolution of an emerging plant pathogen in Australia

open access: yes
<p>Data related to the manuscript "Rapid clonal expansion and adaptation from standing genetic variation underpin the evolution of an emerging plant pathogen in Australia"</p ...
Vaghefi, Niloofar
core   +1 more source

Evolving copy number gains promote tumor expansion and bolster mutational diversification

open access: yesNature Communications
The timing and fitness effect of somatic copy number alterations (SCNA) in cancer evolution remains poorly understood. Here we present a framework to determine the timing of a clonal SCNA that encompasses multiple gains.
Zicheng Wang   +7 more
doaj   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

open access: yesAdvanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker   +7 more
wiley   +1 more source

Prostate Cancer Patient‐Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)‐Based Personalized Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
Prostate patient‐derived organoids (PDOs) were established from TURP and biopsy specimens with >90% success and retain key features of their tissues of origin, making them functional avatars for antisense oligonucleotide (ASO) therapy . Transfecting single cells outside the Matrigel matrix and then reconstituting organoids overcomes the 3D delivery ...
Thi Thom Tran   +15 more
wiley   +1 more source

Rational Control of Antibody Orientation for Enhancing Sensitivity and Specificity in Lateral Flow Immunoassays With Clinical Validation

open access: yesAdvanced Healthcare Materials, EarlyView.
Systematic investigation of antibody orientation strategies in lateral flow immunoassays reveals that a para‐substituted (aminomethyl)phenylboronic acid mediated probe (P‐6) combined with a biotin‐streptavidin test‐line modification achieves a synergistic 14‐ to 19‐fold sensitivity gain over conventional conjugation. Furthermore, multiplexed detection,
Pin‐Hao Wang   +5 more
wiley   +1 more source

Elucidating Factors That Influence Clonal Expansion Rate in Individuals with Clonal Hematopoiesis

open access: yes
Clonal hematopoiesis (CH) is a common age-related condition characterized by an acquired somatic mutation in a hematopoietic stem cell that confers a growth advantage. Patients with CH have an increased risk of numerous conditions including blood cancer,
Mack, Taralynn Marie
core  

Loss of T Cell CD98 H Chain Specifically Ablates T Cell Clonal Expansion and Protects from Autoimmunity

open access: yes, 2011
CD98 H chain (4F2 Ag, Slc3a2) was discovered as a lymphocyte-activation Ag. Deletion of CD98 H chain in B cells leads to complete failure of B cell proliferation, plasma cell formation, and Ab secretion. In this study, we examined the role of T cell CD98
Nil Ege   +4 more
core   +1 more source

GNLY+CD8+ T cells bridge premature aging and persistent inflammation in people living with HIV

open access: yesEmerging Microbes and Infections
People living with HIV (PLWH) exhibit accelerated aging, characterized by systemic inflammation, termed “inflammaging.” While T-cell expansion is prevalent in PLWH, its connection to inflammaging remains unclear.
Hui-Fang Wang   +17 more
doaj   +1 more source

Pressure‐Assisted Drug Delivery Using High‐Pressure Balloon Platform Improves Vascular Drug Penetration and Anti‐Restenotic Effects

open access: yesAdvanced Healthcare Materials, EarlyView.
A dual‐layer high‐pressure drug‐coated balloon (HP@DCB) increased balloon‐wall contact and promoted deeper paclitaxel (PTX) penetration than a conventional noncompliant DCB. In in vivo study, HP@DCB treatment improved luminal patency and reduced neointimal hyperplasia, supporting pressure‐assisted drug delivery as a promising strategy for enhancing the
Seung Jin Eo   +10 more
wiley   +1 more source

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