Results 181 to 190 of about 3,725,865 (331)

Glucose induces clonal selection and reversible dinucleotide repeat expansion in mesangial cells isolated from glomerulosclerosis-prone mice

, 2003
Clonal selection has been proposed as a pathogenetic mechanism in various chronic diseases, such as scleroderma, hypertension, pulmonary fibrosis, interstitial fibrosis of the kidney, atherosclerosis, and uterine leiomyomatosis.
Striker, Gary E, Striker, Liliane J, Lenz, Oliver, Fornoni, Alessia   +3 more
core   +1 more source

Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform

Advanced Healthcare Materials, EarlyView.
A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu, Xinggui Tian, Anne Bernhardt, Anja Lode, Max von Witzleben, Ege Kirbas, Stefan Zwingenberger, Michael Gelinsky   +7 more
wiley   +1 more source

Photoacoustic Nanotagging for In Vivo Tracking and Optimization of Macrophage Immunotherapy in Solid Tumors

Advanced Materials, EarlyView.
Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song, Melissa Cadena, Myeongsoo Kim, Euisuk Chung, Jeungyoon Lee, Zlata Brushevich, Seonghun Shin, Paul S. Pelkowski, Stanislav Y. Emelianov   +8 more
wiley   +1 more source

Immunophenotypic profile and in vitro clonal expansion capacity of circulating and bone marrow derived endothelial cells: a comparison with endothelial –like cells

, 2006
Immunophenotypic profile and in vitro clonal expansion capacity of circulating and bone marrow derived endothelial cells: a comparison with endothelial –like ...
LANZA, Francesco, CUNEO, Antonio, Moretti S, Ferrari L, CAMPIONI, Diana   +4 more
core  

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Clonal hematopoiesis in the pathogenesis of non-hematologic diseases with therapeutic potential

Cancer Cell International
Clonal hematopoiesis (CH) — clonal expansion of hematopoietic stem or progenitor cells due to somatic mutation — is associated with increased pathogenic risk and inferior clinical outcome of multiple diseases other than hematological diseases, such as ...
Lu Lei, Jie Xiong
doaj   +1 more source

Nonlocomotory Robotic Strategies for Dynamic Rotation Control in Terrestrial Robots: A Review

Advanced Robotics Research, EarlyView.
Terrestrial robots increasingly require rapid body rotation to maintain stability and agility in complex environments. This review shows nonlocomotory rotational control strategies that operate without ground contact, including reaction wheels, tails, bars, limbs, and thrusters.
Y. Liang, J. An, X. Zheng, D. Wang, S. Wang, X. Wang, P. Zhu, J. Pei, S. Li, J. Paripurana, Y. Han, Z. Tang, X. Gan, Q. He, X. Ma   +14 more
wiley   +1 more source

A State‐Adaptive Koopman Control Framework for Real‐Time Deformable Tool Manipulation in Robotic Environmental Swabbing

Advanced Robotics Research, EarlyView.
This work presents a state‐adaptive Koopman linear quadratic regulator framework for real‐time manipulation of a deformable swab tool in robotic environmental sampling. By combining Koopman linearization, tactile sensing, and centroid‐based force regulation, the system maintains stable contact forces and high coverage across flat and inclined surfaces.
Siavash Mahmoudi, Amirreza Davar, Dongyi Wang   +2 more
wiley   +1 more source

Push the Limits: Human‐Like Multimodal Extreme Embodied Intelligence for Autonomous Racing

Advanced Robotics Research, EarlyView.
Autonomous racing tests embodied intelligence under extreme control limits of speed, actuation, and decision‐making. Inspired by human multimodality, we present Apex, an embodied agent deployed on a super‐formula racing car at Yas Marina. Integrating physics‐informed perception, multimodal learning, and tasking, Apex cuts lap times by 15% and achieves ...
Yanxin Zhou, Baichuan Lou, Wenhui Huang, Binbin Hu, Haohan Yang, Haochen Liu, Xiangkun He, Chee Kiong Ong, Yiran Zhang, Tianchu Su, Bolin Zhao, Xiaoyu Mo, Holden King Ho Li, Chen Lv   +13 more
wiley   +1 more source

Clonal expansion mechanisms in paroxysmal nocturnal hemoglobinuria

International Journal of Hematology
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-dependent intravascular hemolysis and thrombosis as well as bone marrow failure. Complement dysregulation occurs as a result of defective cell surface expression of two glycosylphosphatidylinositol (GPI)-anchored complement regulators, decay-accelerating factor/CD55 and CD59 ...
openaire   +2 more sources