Results 181 to 190 of about 107,781 (288)

Atypical memory B cell clonal expansion and inflammatory programs associate with platelet-activating antibody development in COVID-19. [PDF]

JCI Insight
Witman N, Yu M, Zhang Y, Gai K, Chen Y, Zhou L, Nguyen C, Zhu W, Zheng Y, Jobe S, Graham MB, Cui W, Wang D, Wen R.   +13 more
europepmc   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Clonal Expansion of <i>penA</i>-60.001 in Cephalosporin-Resistant <i>Neisseria gonorrhoeae</i>: A Molecular Epidemiology Study in Meizhou, China, 2020-2024. [PDF]

Infect Drug Resist
Li Q, Qiu Q, Gu H, Huang Z, Luo Y, Guo X.   +5 more
europepmc   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Elucidating Factors That Influence Clonal Expansion Rate in Individuals with Clonal Hematopoiesis

Clonal hematopoiesis (CH) is a common age-related condition characterized by an acquired somatic mutation in a hematopoietic stem cell that confers a growth advantage. Patients with CH have an increased risk of numerous conditions including blood cancer,
Mack, Taralynn Marie
core  

Sesaminol Inhibits Adipogenesis by Suppressing Mitotic Clonal Expansion and Activating the Nrf2-ARE Pathway. [PDF]

Nutrients
Nakamatsu S, Nakata M, Norikura T, Sasaki Y, Matsui-Yuasa I, Omura A, Kiyomoto K, Kojima-Yuasa A.   +7 more
europepmc   +1 more source

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Tumor-targeted IL2 promotes specific CD8⁺ T cells private clonal expansion enhancing lymphoma control. [PDF]

J Exp Clin Cancer Res
Virgilio T, Chahine K, Bansal H, Pizzichetti C, Renner LL, Capucetti A, Bilato G, Latino I, Morone D, Pulfer A, Ventura P, Mele F, Puca E, Mangani D, Junqueira C, Sallusto F, Neri D, De Luca R, Gonzalez SF.   +18 more
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Systems mapping of intra-donor, cross-tissue T cell clonal expansion and tissue adaptation in the gut-liver-blood axis. [PDF]

Cell Rep
Ran R, Uslu M, Siddiqui MF, Brubaker DK, Trapecar M.   +4 more
europepmc   +1 more source