Results 201 to 210 of about 107,781 (288)

Molecular Surveillance of Malaria in Nigeria Reveals a Low Frequency of Antimalarial Resistance Markers and Clonal Expansion of Chloroquine-Sensitive Infections. [PDF]

Open Forum Infect Dis
Ajibaye O, Oboh-Imafidon M, Ajibola O, Olusola F, Egwu CO, Amambua-Ngwa BN, Diop MF, Mohammed N, D'Alessandro U, Falade C, Meremikwu M, Olukosi AY, Oriero EC, Amambua-Ngwa A.   +13 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion. [PDF]

J Clin Invest
Mannino G, Quinn G, Zhu M, Wang Z, Wang X, Li B, Hsieh MH, Mathews T, Zacharias L, Gu W, Gopal P, Brzozowska N, Campbell P, Hoare M, Liszczak G, Zhu H.   +15 more
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer. [PDF]

J Immunother Cancer
Yu H, Magoulopoulou A, Amini RM, Chatzinikolaou MP, Horie M, Lindberg A, Mezheyeuski A, Backman M, Metousis A, Brunnström H, Marincevic M, Botling J, Mattsson JSM, Kärre K, Leandersson K, Nilsson M, Strell C, Micke P.   +17 more
europepmc   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Genomic Epidemiology of <i>Salmonella enterica</i> Serovar Give Reveals Clonal Expansion and Increasing Prevalence of <i>qnrB19</i> - China, 2017-2024. [PDF]

China CDC Wkly
Sun B, Fan F, Cui Z, Du X, Wang J, Zhou H, Kan B, Yan M.   +7 more
europepmc   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source