Results 111 to 120 of about 389,564 (265)

Liquid biopsy across cancers: Integrating circulating biomarkers, tumor biology, artificial intelligence, and clinical translation

Interdisciplinary Medicine, EarlyView.
Liquid biopsy uses non‐invasive sampling of blood or body fluids to isolate circulating analytes, including circulating tumor DNA, circulating tumor cells, extracellular vesicles, and RNA. These are analyzed using next‐generation sequencing, qPCR, and proteomics to inform cancer detection, monitoring, and characterization. Figure created with BioRender.
Jaswinder Singh, Manjeet Kumar, Kajal Kamra   +2 more
wiley   +1 more source

Effects of Organic Fertilizer Substitutions on Latex Yield and Soil Fertility in Hevea brasiliensis Plantations: A Case Study in Southern Philippines

Land Degradation &Development, EarlyView.
ABSTRACT Rubber plantations can be a major source of income for small landholder farmers in rural communities across Southern Asia. However, rising fertilizer costs and progressive soil degradation threaten long‐term productivity and economic viability.
Oscar Jurado, Chengrong Chen, Johnvie B. Goloran, Adeflor Garcia, Honey B. Goloran, Xiangyu Liu, Neal W. Menzies, Yunying Fang   +7 more
wiley   +1 more source

REPRODUCTIVE PROCESSES IN CLONAL PLANTATIONS OF EUROPEAN SPRUCE OF FINNISH ORIGIN IN THE CONTEXT OF SUSTAINABLE FORESTRY

Agriculture and Forestry
The study examines the peculiarities of reproductive processes in clonal plantations of European spruce (Picea abies (L.) Karst.) of Finnish origin in the context of sustainable forestry. The research is based on the analysis of generative structures' formation, specifically microstrobili and macrostrobili, as well as the general physiological state of
Ihor Neyko, Mikhailo Matusiak, Serhii Razanov, Alla Razanova, Halyna Mudrak   +4 more
openaire   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Bulbophyllum weddellii (Orchidaceae) demonstrates foliar water uptake plasticity along Brazilian campos rupestres

Nordic Journal of Botany, EarlyView.
Phenotypic plasticity can facilitate species survival in a variety of conditions that are not possible with a fixed phenotype. Foliar water uptake (FWU), defined as the absorption of water through leaf surfaces, is an important mechanism contributing to plant water balance and drought tolerance in many species.
Daniela Boanares, Lucas Erickson Nascimento da Costa, Markus Gastauer, Cecílio Caldeira, Cecilia F. Fiorini   +4 more
wiley   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Conservation gap analysis for wild grapevines (Vitis L.) of the Americas

PLANTS, PEOPLE, PLANET, EarlyView.
Wild grapevines (Vitis L.) native to the Americas are ecologically and culturally important plants that are also critical to the global cultivated grape industry as sources of traits for crop innovation, but many of these species are poorly documented and insufficiently conserved.
Daniel Carver, Colin K. Khoury, Anne Frances, Nan McCarry, Luis Diaz‐Garcia, Erin R. Galarneau, Sarah Gora, Megan Haidet, Claire Heinitz, Wesley Knapp, Abby Meyer, Allison Miller, Ray Mims, Surya Sapkota, Carol Spurrier, Jun Wen   +15 more
wiley   +1 more source

Multiple barriers maintain species boundaries in sympatric brood‐site deceptive Gastrodia orchids

PLANTS, PEOPLE, PLANET, EarlyView.
Societal Impact Statement Gastrodia orchids are inconspicuous forest plants that lack chlorophyll and obtain carbon from fungi. Their dull‐colored, ground‐level flowers are often hidden among leaf litter, yet they rely on small flies for pollination.
Kenji Suetsugu, Akihiro Nishimura, Shun K. Hirota, Masahito T. Kimura   +3 more
wiley   +1 more source