Results 151 to 160 of about 389,564 (265)

Host genotype, resistance status and seasonal temperature shape the Norway spruce phyllosphere mycobiome. [PDF]

PLoS One
Ren W, Wen Z, Wang K, Azeez AA, Asiegbu FO.   +4 more
europepmc   +1 more source

Complement receptor C3aR marks heterogeneous tumor‐associated macrophage states associated with improved survival in IDH‐wildtype glioblastoma

Brain Pathology, EarlyView.
C3aR expression in IDH‐wildtype glioblastoma is predominantly associated with the myeloid/macrophage compartment and heterogeneous macrophage states. C3aR‐high tumors are enriched among MGMT promoter‐methylated tumors and show improved overall survival, although the prognostic association requires independent validation.
Marion Imara, Yosra Bedoui, Théotime Pignolet, Sebastien Freppel, Camille Brochard, Auguste Delattre, David Cappellen, Luc Bauchet, Mohamed Khettab, Franck Ah‐Pine   +9 more
wiley   +1 more source

Being Female Matters: Drivers of Spatial Genetic Structure in Clonal White Poplar. [PDF]

Int J Mol Sci
Terlecka M, Iszkuło G, Dering M, Rabska M, Walas Ł, Sękiewicz K.   +5 more
europepmc   +1 more source

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients

Brain Pathology, EarlyView.
In a molecularly confirmed cohort of 64 newly diagnosed, TTFields‐treated glioblastomas, IDH‐wildtype, homozygous PTEN deletion was associated with markedly shorter overall survival (368 vs. 603 days) and remained an independent adverse prognostic factor.
Jakob Nückles, Claudius Jelgersma, Christin Siewert, Brendan Osberg, Simone Schmid, Arend Koch, Eilís Perez, Daniel Teichmann, Martin Misch, Anna‐Gila Karbe, Susanne Ukrow, Patrick N. Harter, Ruth M. Stassart, Peter Vajkoczy, Julia Onken, David Capper   +15 more
wiley   +1 more source

Genetic Diversity and Clonal Structure of Small-Leaved Lime (<i>Tilia cordata</i> Mill.) in Lithuanian Protected Forest Areas. [PDF]

Plants (Basel)
Verbylaitė R, Lynikienė J, Gedminas A, Mishcherikova V, Baliuckas V, Suchockas V.   +5 more
europepmc   +1 more source

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

Inbreeding depression in diploid potato: genetic basis, deleterious load, and breeding mitigation. [PDF]

Front Plant Sci
Wang Y, Lin T, Wang W, Wang Y, Fan L, Huang W, Jiao X, Wang Z, Wu H, Zong X, Zheng A, Yang F, Zhang B, Yu J, Chen J, Yin Y.   +15 more
europepmc   +1 more source

TERT Promoter Mutations Are Preferentially Associated With the ERBB2 G776‐Altered Subtype of HER2‐Mutant NSCLC

Cancer Science, EarlyView.
A two‐stage clinicogenomic analysis identified and independently validated a preferential association between TERT promoter mutations and the ERBB2 G776‐altered subtype of HER2‐mutant NSCLC, highlighting subtype‐specific genomic heterogeneity. ABSTRACT HER2‐mutant non‐small cell lung cancer (NSCLC) comprises molecularly heterogeneous tumors with ...
Akihiro Yoshimura, Juichiro Yoshida, Chieko Takumi, Koichi Takayama   +3 more
wiley   +1 more source

Drought Intensity, Timing, and Reproductive Strategy Drive Submerged Macrophyte Resilience. [PDF]

Plants (Basel)
He Y, Liu P, Zhang C, Wang Z, Zhang X, Guo K, Zhang Y, Lei J, Zhou J, Zeng Q, Lu C, Lei T, Wen L, Lei G.   +13 more
europepmc   +1 more source

Machine Learning‐Derived Immune Gene Signature Predicts Prognosis and Therapeutic Vulnerabilities in Multiple Myeloma

Cancer Science, EarlyView.
An immune‐related 12‐gene signature developed through integrative machine learning stratified overall survival across multiple myeloma cohorts and remained independently associated with outcome. Single‐cell, somatic mutation, and transcriptome‐based drug‐response analyses further linked the signature to multicellular bone marrow context, distinct ...
Kai Wang, Chenfei Zhao, Jingru Shi, Shiwei Liu, Yi Chen, Jujuan Wang, Zhengxu Sun, Sanmei Wang, Lei Fan, Jin Fan, Xiaoyan Qu   +10 more
wiley   +1 more source