Results 91 to 100 of about 23,625 (255)

Estimating fitness from offspring counts in clonal seed plants

Ideas in Ecology and Evolution, 2014
Should asexual/vegetative offspring be counted in estimates of evolutionary fitness in seed plants? The answer it seems remains debatable among evolutionary ecologists.
Lonnie Aarssen
doaj  

Root hemiparasites suppress invasive alien clonal plants: evidence from a cultivation experiment [PDF]

NeoBiota
Alien invasive plants threaten biodiversity by rapid spread and competitive exclusion of native plant species. Especially, tall clonal invasives can rapidly attain strong dominance in vegetation. Root-hemiparasitic plants are known to suppress the growth
Tamara Těšitelová, Kateřina Knotková, Adam Knotek, Hana Cempírková, Jakub Těšitel   +4 more
doaj   +3 more sources

Extensive clonal spread and extreme longevity in saw palmetto, a foundation clonal plant

Molecular Ecology, 2011
AbstractThe lack of effective tools has hampered out ability to assess the size, growth and ages of clonal plants. WithSerenoa repens(saw palmetto) as a model, we introduce a novel analytical framework that integrates DNA fingerprinting and mathematical modelling to simulate growth and estimate ages of clonal plants. We also demonstrate the application
Takahashi, Mizuki K, Horner, Liana M, Kubota, Toshiro, Keller, Nathan A, Abrahamson, Warren G., II   +4 more
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Vegetative Propagation Preserves Genomic Diversity and Informs Translocation Strategies in a Rare Clonal Plant

Evolutionary Applications
Conservation translocations are widely used to increase population size and redundancy, yet their genetic consequences are often uncertain, particularly for clonal species with unknown rates of sexual reproduction.
Rob Massatti, Susan Bainbridge, Stella M. Copeland, Carter Crouch, Trevor M. Faske, Erik P. Hamerlynck, Brandon Palmer, Carla M. Roybal   +7 more
doaj   +1 more source

Clonal Micropropagation of Promising Genotypes of Amygdalus communis L. for Population Restoration and Gene Pool Conservation

Horticulturae
The southern region of Kazakhstan represents the northernmost boundary of the natural habitat of five wild almond species, among which Amygdalus communis L.
Timur Turdiyev, Kumissay Duisenova, Irina Kovalchuk, Aigul Madenova, Saule Baizhumanova, Kamila Yemesheva, Natalya Mikhailenko, Zakir Tuigunov   +7 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source