Results 81 to 90 of about 84,467 (284)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Anticipatory Behavior of the Clonal Plant Fragaria vesca [PDF]

Frontiers in Plant Science, 2018
Active foraging for patchy resources is a crucial feature of many clonal plant species. It has been recently shown that plants' foraging for resources can be facilitated by anticipatory behavior via association of resource position with other environmental cues.
Vít Latzel, Zuzana Münzbergová, Zuzana Münzbergová   +2 more
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Adjusting to global change through clonal growth and epigenetic variation

Frontiers in Ecology and Evolution, 2016
The earth is experiencing major changes in global and regional climates and changes are predicted to accelerate in the future. Many species will be under considerable pressure to evolve, to migrate, or be faced with extinction. Clonal plants would appear
Richard S Dodd, Vladimir Douhovnikoff
doaj   +1 more source

Seedling Emergence from Seed Banks in Ludwigia hexapetala-Invaded Wetlands: Implications for Restoration [PDF]

, 2019
Soil seed banks play a critical role in the maintenance of wetland plant communities and contribute to revegetation following disturbances. Analysis of the seed bank can therefore inform restoration planning and management.
Castillo Segura, Jesús Manuel, Futrell, Caryn J., Gillard, Morgane B., Grewell, Brenda J.   +3 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Genetic draft, selective interference, and population genetics of rapid adaptation [PDF]

, 2013
To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetic inference is based on frameworks assuming adaptive evolution is rare.
Neher, Richard A.
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Evidence for suppression of immunity as a driver for genomic introgressions and host range expansion in races of Albugo candida, a generalist parasite [PDF]

, 2015
How generalist parasites with wide host ranges can evolve is a central question in parasite evolution. Albugo candida is an obligate biotrophic parasite that consists of many physiological races that each specialize on distinct Brassicaceae host species.
Abbott, Altschul, Baack, Barbetti, Baxter, Biga, Blanco, Boni, Borhan, Choi, Choi, Choi, Conesa, Cooper, Diogo, Dodds, Dong, Doolittle, Drummond, Drès, Dujon, Eddy, Ersek, Farrer, Fontaine, Galagan, Greig, Haas, Hacquard, Harper, Haubold, Heath, Hedrick, Hiura, Hobolth, Holub, Huelsenbeck, Jukes, Jurka, Kemen, Kent, Kole, Lamichhaney, Lamour, Langmead, Lebrun, Levesque, Li, Li, Links, Liu, Liu, Lomsadze, Martin, Martin, Martin, McHale, Mckinney, Meena, Mehrabi, Mehta, Moller, Monod, Nagahara, Nichols, Padidam, Pamilo, Parker, Parra, Payen, Petersen, Petrie, Ploch, Posada, Poulin, Pound, Price, Pruitt, Punta, Quinlan, Rimmer, Ruderfer, Saharan, Schulz, Seehausen, Smith, Soanes, Sommer, Stanke, Stukenbrock, Stukenbrock, Stukenbrock, Suzek, Tajima, The Arabidopsis Genome Initiative, Thines, Thines, Thompson, Tyler, Ungerer, Usher, Voglmayr, Walker, Zerbino   +103 more
core   +3 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source