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Clonality in Myelodysplastic Syndromes
Leukemia and Lymphoma, 1994Myelodysplastic syndromes (MDS) comprises a group of acquired hematological disorders which is characterized by a progressive peripheral blood pancytopenia of one or more cell lineages. A high percentage of blast cells in either bone marrow or peripheral blood predisposes for the transformation to acute myeloid leukemia.
J H Bourhis
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Clonality of Multiple Meningiomas
Journal of Neuro-Ophthalmology, 1997✓ A significant number of patients with meningiomas develop multiple tumors without anatomical bridges. To understand the mechanism by which multiple meningiomas arise, the authors analyzed DNA from 39 multiple meningiomas in 12 patients to locate alterations in the neurofibromatosis type 2 (NF2) gene.
A P, Stangl +7 more
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Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules
Hepatology, 1991To determine the clonal evolution of hepatocellular carcinoma, the integrated hepatitis B virus DNA patterns of the main tumor, satellites and/or metastatic lesions were analyzed by Southern-blot hybridization in 28 hepatocellular carcinomas, including three HBsAg-seronegative cases.
H C, Hsu +5 more
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Tackling the population genetics of clonal and partially clonal organisms
Trends in Ecology & Evolution, 2005Many clonal organisms experience occasional events of sexual recombination, with profound consequences for their population dynamics and evolutionary trajectories. With the recent development of polymorphic genetic markers and new statistical methods, we now have an unprecedented ability to detect recombination in organisms that are thought to ...
Halkett, Fabien +2 more
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Clonal Analysis of Meningiomas
Neurosurgery, 1996Meningiomas are primary brain tumors arising from meningothelial cells. They usually grow slowly and are surgically easy to separate from the brain. A recent clonal analysis of meningiomas, using methylation-sensitive restriction fragment length polymorphisms, suggested a monoclonal origin.
Jilian K. Wu +6 more
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Human Pathology, 1997
In malignant gliomas, the characteristically heterogeneous features and frequent diffuse spread within the brain have raised the question of whether malignant gliomas arise monoclonally from a single precursor cell or polyclonally from multiple transformed cells forming confluent clones.
M M, Kattar +6 more
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In malignant gliomas, the characteristically heterogeneous features and frequent diffuse spread within the brain have raised the question of whether malignant gliomas arise monoclonally from a single precursor cell or polyclonally from multiple transformed cells forming confluent clones.
M M, Kattar +6 more
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2008
AbstractAbout 99.9% of vertebrate species reproduce sexually. This makes the exceptional 0.1%—the asexual or clonal reproducers—fascinating in their own right, and also uniquely instructive about the biological significance of alternative reproductive modes. This book describes the genetics, ecology, natural history, and evolution of all of the world's
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AbstractAbout 99.9% of vertebrate species reproduce sexually. This makes the exceptional 0.1%—the asexual or clonal reproducers—fascinating in their own right, and also uniquely instructive about the biological significance of alternative reproductive modes. This book describes the genetics, ecology, natural history, and evolution of all of the world's
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Clonal Origin and Clonal Selection in PNH
2017Paroxysmal nocturnal haemoglobinuria (PNH) is a haemolytic anaemia with rather unique features; indeed, (a) it is also associated with features of bone marrow failure; (b) it is acquired but it is due to an intrinsic red cell abnormality; and (c) it is a clonal disorder of haematopoiesis, but it is not a malignancy.
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Nature, 1982
The development of cancer is contingent on the emergence of at least one clone of transformed cells. One method used to investigate whether human tumours are monoclonal depends on the mosaicism in the normal tissues of women heterozygous for the two forms of the enzyme glucose-6-phosphate dehydrogenase (G-6-PD).
Woodruff, M F +5 more
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The development of cancer is contingent on the emergence of at least one clone of transformed cells. One method used to investigate whether human tumours are monoclonal depends on the mosaicism in the normal tissues of women heterozygous for the two forms of the enzyme glucose-6-phosphate dehydrogenase (G-6-PD).
Woodruff, M F +5 more
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Engineering Applications of Artificial Intelligence, 2008
The aim of this paper is to design an efficient and fast clonal algorithm for solving various numerical and combinatorial real-world optimization problems effectively and speedily, irrespective of its complexity. The idea is to accurately read the inherent drawbacks of existing immune algorithms (IAs) and propose new techniques to resolve them.
Nitesh Khilwani +3 more
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The aim of this paper is to design an efficient and fast clonal algorithm for solving various numerical and combinatorial real-world optimization problems effectively and speedily, irrespective of its complexity. The idea is to accurately read the inherent drawbacks of existing immune algorithms (IAs) and propose new techniques to resolve them.
Nitesh Khilwani +3 more
openaire +2 more sources