Results 41 to 50 of about 39,199 (304)
How clonal are Neisseria species? The epidemic clonality model revisited [PDF]
, 2015 The three species Neisseria meningitidis, Neisseria gonorrheae, and Neisseria lactamica are often regarded as highly recombining bacteria. N. meningitidis has been considered a paradigmatic case of the "semiclonal model" or of "epidemic clonality ...
Tibayrenc, Michel, Ayala, Francisco J
core +1 more source
Impact of HLA zygosity on repertoire richness and clonality.
, 2021 HLA zygosity at neither (A) class I loci (Spearman rho = 0.011, p = 0.08) nor (B) class II loci were correlated with Simpson clonality (-0.023, p = 0.64). Overall, HLA zygosity in this cohort was not correlated with (C) richness (Spearman rho = 0.026, p =
Spencer L. Seale (11355820) +5 more
core +1 more source
Microbiology Spectrum, 2022 Escherichia coli sequence type 131 (ST131) is a pandemic, multidrug-resistant extraintestinal pathogen. The multiple distinctive ST131 subclones differ for rfb and fliC alleles (O and H antigens), fimH allele (type-1 fimbriae adhesin), resistance ...
Brian D. Johnston +6 more
doaj +1 more source
Clonal hematopoiesis in cancer
Experimental Hematology, 2020 Clonal hematopoiesis is a common premalignant condition defined by the abnormal expansion of clonally derived hematopoietic stem cells carrying somatic mutations in leukemia-associated genes. Apart from increasing age, this phenomenon occurs with higher frequency in individuals with lymphoid or solid tumors and is associated with exposures to genotoxic
Park, Soo J, Bejar, Rafael
openaire +5 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in Oncology, 2018 Drug resistance constitutes a major challenge in designing melanoma therapies. Microenvironment-driven tumor heterogeneity and plasticity play a key role in this phenomenon. Melanoma is highly heterogeneous with diverse genomic alterations and expression
Farzana Ahmed +2 more
doaj +1 more source
Journal of Marine Science and Engineering, 2023 Seagrasses are marine angiosperms, and seagrass beds maintain the species diversity of tropical and subtropical coastal ecosystems. For proper understanding, management and conservation of coastal ecosystems, it is essential to understand seagrass ...
Yuichi Nakajima +6 more
doaj +1 more source
Human tumour clonality assessment--flawed but necessary.
, 2008 One of the premises of the somatic mutation theory of carcinogenesis is that tumours are clonal lesions derived from a single mutated stem cell progenitor.
Leedham, SJ, Wright, NA
core +1 more source
Exploring the Genetic Consequences of Clonality in Haplodiplontic Taxa
, 2020 International audiencePartially clonality is an incredibly common reproductive mode found across all the major eukaryotic lineages. Yet, population genetic theory is based on exclusive sexuality or exclusive asexuality, and partial clonality is often ...
Krueger-Hadfield, Stacy +5 more
core +1 more source