Statistical Tests for Clonality [PDF]
Biometrics, 2006 Summary Cancer investigators frequently conduct studies to examine tumor samples from pairs of apparently independent primary tumors with a view to determine whether they share a “clonal” origin. The genetic fingerprints of the tumors are compared using a panel of markers, often representing loss of heterozygosity (LOH) at distinct genetic loci.
Begg, Colin B. +2 more
openaire +2 more sources
Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci [PDF]
, 2013 African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
C. Michael R. Turner +54 more
core +1 more source
Impact of CMV Infection on Natural Killer Cell Clonal Repertoire in CMV-Naïve Rhesus Macaques
Frontiers in Immunology, 2019 Recent functional, gene expression, and epigenetic studies have suggested the presence of a subset of mature natural killer (NK) cells responsible for maintaining NK cell memory. The lack of endogenous clonal markers in NK cells impedes understanding the
Lauren L. Truitt +15 more
doaj +1 more source
Coexistence of Multiple Endemic and Pandemic Lineages of the Rice Blast Pathogen
mBio, 2018 The rice blast fungus Magnaporthe oryzae (syn., Pyricularia oryzae) is both a threat to global food security and a model for plant pathology. Molecular pathologists need an accurate understanding of the origins and line of descent of M.
Pierre Gladieux +9 more
doaj +1 more source
Ecology and Evolution, 2021 Dispersal and colonization are among the most important ecological processes for species persistence as they allow species to track changing environmental conditions.
Graham E. Wyatt +2 more
doaj +1 more source
Culture-adapted Plasmodium falciparum isolates from UK travellers: in vitro drug sensitivity, clonality and drug resistance markers. [PDF]
, 2013 BACKGROUND: The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century.
Sutherland, CJ +18 more
core +1 more source
Next-Generation Sequencing-Based Clonality Detection of Immunoglobulin Gene Rearrangements in B-Cell Lymphoma [PDF]
, 2022 Immunoglobulin (IG) clonality assessment is a widely used supplementary test for the diagnosis of suspected lymphoid malignancies. The specific rearrangements of the immunoglobulin (IG) heavy and light chain genes act as a unique hallmark of a B-cell ...
Last-Kempkes, J.L.M. van der +3 more
core +1 more source
Clonality analysis of lymphoid proliferations using the BIOMED-2 clonality assays: a single institution experience [PDF]
, 2014 Background. Clonality determination in patients with lymphoproliferative disorders can improve the final diagnosis.The aim of our study was to evaluate the applicative value of standardized BIOMED-2 gene clonality assay protocolsfor the analysis of ...
Srdjan Novakovic +7 more
core +1 more source
Characterisation of Campylobacter spp. Isolated from Poultry in KwaZulu-Natal, South Africa
Antibiotics, 2020 This study investigated the antibiotic resistance, virulence profiles, and clonality of Campylobacter jejuni and Campylobacter coli isolated from an intensive poultry farming system in KwaZulu-Natal, South Africa. Following ethical approval, samples were
Stephanie Pillay +7 more
doaj +1 more source
Journal of Veterinary Internal Medicine, 2021 Background Differentiation of low‐grade intestinal T‐cell lymphoma (LGITL) from lymphoplasmacytic enteritis (LPE) in cats is a diagnostic challenge for pathologists.
Valérie Freiche +9 more
doaj +1 more source