Results 31 to 40 of about 20,877 (202)

Clonazepam Acetylation in Fast and Slow Acetylators

, 1981
Six slow acetylators (SAs) and six rapid acetylators (RAs), as determined by sulfamethazine (SMZ) phenotyping, were each given a 2-mg oral dose of clonazepam.
B H Min, Garland, W. A., Ludwick, B. T., Miller, Marvin E., Levy, R. H., R H Ballard, R H Levy, Min, B. H., Ballard, R. H., M E Miller, B T Ludwick, W A Garland   +11 more
core   +1 more source

Benzodiazepines use in primary care England: Prescribing patterns and adverse consequences

British Journal of Clinical Pharmacology, EarlyView.
Aims Benzodiazepines (BZDs) are commonly prescribed for anxiety and insomnia but carry risks such as dependence, adverse drug reactions (ADRs) and mortality. Despite deprescribing efforts, the influence of recent prescribing trends, COVID‐19 and adverse outcomes on prescribing patterns in England remains uncertain.
Alvina Chaudhry, Muhammad Umair Khan, Barbara Conway, Syed Shahzad Hasan   +3 more
wiley   +1 more source

Stability Studies of Clonazepam 2.5 mg/mL Oral Solution and 1 mg/mL Parenteral Solution in Pre-Filled Polypropylene Syringes

Pharmaceutics
Background: Clonazepam is a benzodiazepine drug indicated in all clinical forms of epileptic seizures, various forms of myoclonic seizures, myoclonus and other abnormal movements.
Juan Carlos Ruiz Ramirez, Icram Talsi Hamdani, Laura Bermúdez Gazquez, Alice Charlotte Viney, José M. Alonso Herreros   +4 more
doaj   +1 more source

GRIA2 Variant Associated With Paradoxical Response to Perampanel Expanding the Spectrum of GRIA2‐Related Epileptic Encephalopathy: Case Report and Literature Review

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata, Chhitij Tiwari, Zheng Fan, Muge Gucsavas‐Calikoglu, Yael Shiloh‐Malawsky, Kimberly S. Foss, Stephanie N. Peck, Erin L. Heinzen, Chon Lee, Senyene E. Hunter   +9 more
wiley   +1 more source

Protocolo de Desprescrição do Clonazepam em Idosos

, 2019
Protocolo de Desprescrição do Clonazepam em Idosos - Folheto sobre os benefícios da retirada do clonazepam em idosos após todas as etapas de ...
Marcos Antonio Anacleto Junior
core   +1 more source

Prescripción de clonazepam tabletas en el municipio Santa Clara [PDF]

, 2023
Introduction: Benzodiazepines are drugs used for anxiety and sleep disorders, as well as muscle relaxants and anticonvulsive. Despite being discouraged in prolonged treatments, some patients have chronic use, which is associated with the development of ...
Alemán-Fernández, Eliezer
core  

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart, Gelareh Abulwerdi, Christin L. Daniels, Calib Choi, Rebecca Racz, Jean‐Pierre Valentin, Kristin Ardlie, Nicholas Tatonetti, Susan Laffan, Marjory Moreau, Will Redfern, Lang Li, James J. Hickman, Rajanikanth Madabushi, Bhagwat Prasad, Lynne Yao, Paul B. Watkins   +16 more
wiley   +1 more source

Referent and raw simulated profiles for clonazepam.

, 2018
Graphed are mean (±1 SD) clonazepam concentration profile from the referent clinical bioequivalence study, and the simulated mean clonazepam concentration profile from the ISDAT.
Anika Jhandey (5706785), Zhong Zuo (354195), Jianyuan Deng (1993438), Zhibo Yang (1651024), Kin Fu Patrick Yik (5706788), Tai Ning Lam (5706791), Xiao Zhu (257280)   +6 more
core   +1 more source

Monitoring Injected Drug Use in Greece Through Syringe Residue Analysis: A Multicity Study Within the ESCAPE Network

Drug Testing and Analysis, EarlyView.
A total of 2121 used syringes were analyzed in Athens, Thessaloniki, and Patras between 2022 and 2024. Distinct drug‐use patterns were observed across the three cities. Benzodiazepines, pregabalin, methadone, and fentanyl were increasingly detected in 2024.
Christina Matiaki, Anastasios Trakakis, Athanasios Theocharis, Chara Parpala, Chara Kotsailidou, Alexandros Psarianos, Emmanouil Chatzichristofis, Eleni Zagelidu, Panagiota Roussou, Nikolaos Raikos, Orthodoxia Mastrogianni   +10 more
wiley   +1 more source

Clonazepam and clobazam

, 2018
Clonazepam and clobazam are first-generation antiepileptic drugs characterized by few antiepileptic indications, with good interaction profile in polytherapy.
Andrea E. Cavanna
core   +1 more source