Results 1 to 10 of about 474 (78)

Structure of 1,5-benzodiazepinones in the solid state and in solution: Effect of the fluorination in the six-membered ring [PDF]

Beilstein Journal of Organic Chemistry, 2013
Two novel tetrafluorinated 1,5-benzodiazepinones were synthesized and their X-ray structures determined. 6,7,8,9-Tetrafluoro-4-methyl-1,3-dihydro-2H-1,5-benzodiazepin-2-one crystallizes in the monoclinic P21/c space group and 6,7,8,9-tetrafluoro-1,4 ...
Marta Pérez-Torralba, Rosa M. Claramunt, M. Ángeles García, Concepción López, M. Carmen Torralba, M. Rosario Torres, Ibon Alkorta, José Elguero   +7 more
doaj   +3 more sources

Regioselective One-Pot Synthesis, Biological Activity and Molecular Docking Studies of Novel Conjugates N-(p-Aryltriazolyl)-1,5-benzodiazepin-2-ones as Potent Antibacterial and Antifungal Agents [PDF]

Molecules, 2022
Novel 1,2,3-triazolo-linked-1,5-benzodiazepinones were designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction (CuAAC).
Asma Nsira, Hasan Mtiraoui, Sami Chniti, Hanan Al-Ghulikah, Rafik Gharbi, Moncef Msaddek   +5 more
doaj   +2 more sources

Mannich-Type Condensation and Domino Quinazolinone-Amidine Rearrangement Affords Ring-Fused Mackinazolinones with Anti-Amoebic Activity. [PDF]

Adv Synth Catal, 2023
Abstract A three‐step synthesis of anti‐amoebic, ring‐fused mackinazolinones has been developed. A Mannich‐type reaction between quinazolin‐4‐ones and N‐Cbz propanal in the presence of AgOTf afforded quinazolinones (19–94% isolated yield) bearing a newly formed heterocycle with an alkylamine appendage that, upon N‐Cbz deprotection and basification ...
Lish MS, Milanes JE, Sanders KM, Guzei IA, Morris JC, Golden JE.   +5 more
europepmc   +2 more sources

Copper- and Silver-Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five- and Six-Membered Heterocycles. [PDF]

Chemistry
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
George J, Oh K.
europepmc   +2 more sources

A novel Pd-catalysed sequential carbonylation/cyclization approach toward bis-N-heterocycles: rationalization by electronic structure calculations [PDF]

Royal Society Open Science, 2018
An unprecedented palladium-catalysed sequential aminocarbonylation/cyclization synthetic strategy, using carbon monoxide and structurally different aliphatic diamines as N-nucleophiles, gives access, in one pot, to a new family of indole-based N ...
Liliana Damas, Rui M. B. Carrilho, Sandra C. C. Nunes, Alberto A. C. C. Pais, László Kollár, Marta Pineiro, Mariette M. Pereira   +6 more
doaj   +2 more sources

Copper-promoted synthesis of 1,4-benzodiazepinones via alkene diamination. [PDF]

Tetrahedron Lett, 2015
Karyakarte SD, Sequeira FC, Zibreg GH, Huang G, Matthew JP, Ferreira MM, Chemler SR.   +6 more
europepmc   +2 more sources

Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation. [PDF]

Sci Rep, 2015
Abdelkafi H, Cintrat JC.
europepmc   +2 more sources

Synthesis of Indole‐Fused 1,4‐Diazepinones via Photoredox‐Catalyzed Cascade Cyclization Reaction

Advanced Synthesis &Catalysis, Volume 365, Issue 22, Page 3958-3966, November 21, 2023., 2023
Abstract A photoredox‐promoted approach for the synthesis of [1,4]diazepino[1,7‐a]indol‐6(7H)‐ones starting from N‐indolyl phenylacrylamides and aroyl chlorides as radical source is reported. This method, that involves a cascade radical addition on C−C double bond followed by intramolecular cyclization at indole C2‐position, affords two diastereomeric ...
Elisa Brambilla, Silvia Meraviglia, Edoardo Moneta, Donatella Nava, Silvia Rizzato, Giorgio Abbiati, Valentina Pirovano   +6 more
wiley   +1 more source

Anticancer and Antimicrobial Activity of Some New 2,3‐Dihydro‐1,5‐benzodiazepine Derivatives

Heteroatom Chemistry, Volume 2023, Issue 1, 2023., 2023
A series of 2,3‐dihydro‐1,5‐benzodiazepine derivatives have been synthesized and characterized using IR, NMR, GC‐MS, single crystal XRD, and microanalysis. The results of their antibacterial activity against methicillin‐resistance Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, Streptococcus mutans, Pseudomonas ...
Felix Odame, Tatenda Madanhire, Clement Tettey, David Neglo, Francisca Adzaho, Daniel Sedohia, Eric C. Hosten, Jacek Skarzewski   +7 more
wiley   +1 more source

Challenging Atroposelective C–H Arylation

SynOpen, 2020
Atropisomeric molecules are privileged scaffolds, not only as ligands for asymmetric synthesis, but also as biologically active products and advanced materials.
Joanna Wencel-Delord, Françoise Colobert   +1 more
doaj   +1 more source