Results 21 to 30 of about 628 (148)
Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity
ChemMedChem, Volume 15, Issue 12, Page 1078-1088, June 17, 2020., 2020 The polyphenolic natural product rottlerin, isolated from Kamala powder, has been used for centuries in traditional Indian medicine. Among other biological effects, rottlerin has been shown to activate KCNQ1 potassium channels. Rottlerin analogues were synthesized and evaluated electrophysiologically in X. laevis oocytes.
Marco Lübke +10 more
wiley +1 more source
, 2015 To investigate diazepinone analogues as γ-turn mimics, seven 1,4-benzodiazepin-2-ones 6 and fourteen pyrrolo[1,2-d][1,4]benzodiazepin-6-ones 4 and 5 were synthesized from 1-(2-aminophenyl)pent-4-en-1-one (7).
Aurélie A. Dörr (1566439) +1 more
core +3 more sources
Iridium Catalyzed Asymmetric Hydrogenation of Cyclic Imines of Benzodiazepinones and Benzodiazepines
, 2016 Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was achieved with up to 96% ee.
Zhi-Shi Ye (2058556) +5 more
core +2 more sources
Pd-Catalyzed Allylic C-H Activation to Seven-Membered N,O-Heterocycles [PDF]
, 2021 Pd-catalyzed allylic C-H activation of simple olefins allows an easy entry to seven-membered N,O-heterocycles such as 1,4-benzoxazepines (1,4-BZOs), 1,4-benzodiazepinones (1,4-BZDs) and 1,4-oxazepanes in good to excellent yields.
Velasco Rubio, Álvaro +2 more
core +1 more source
On the reaction of fused benzodiazepines with alkynes containing electron-withdrawing groups
, 2020 Fused benzodiazepines were found to react with activated alkynes to effect either vinylation of unsubstituted nitrogen atom or dealkylation of nitrogen and its further vinylation.
Khrustalev V.N. +7 more
core +2 more sources
Role of Endoplasmic Reticulum Stress in Atherosclerosis and Diabetic Macrovascular Complications
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 Age‐related changes in endoplasmic reticulum (ER) are associated with stress of this cell organelle. Unfolded protein response (UPR) is a normal physiological reaction of a cell in order to prevent accumulation of unfolded and misfolded proteins in the ER and improve the normal ER function.
Dmitry A. Chistiakov +4 more
wiley +1 more source
International Journal of Photoenergy, Volume 3, Issue 4, Page 205-211, 2001., 2001 The photostability of selected drug molecules, including furosemide, prochlorperazine, diclofenac, piroxicam, midazolam and nifedipine was studied, the kinetics of photodegradation, identification of the photodegradants investigated and mechanisms of photodegradation proposed.
B. D. Glass +8 more
wiley +1 more source
Correction: Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones
, 2017 Correction for ‘Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones’ by Hasan Mtiraoui, et al., Org. Biomol. Chem., 2017, 15, 3060–3068.
Morgane Sanselme +5 more
core +1 more source
Electrochemical Intramolecular Aminobromination of Alkenes
European Journal of Organic Chemistry, Volume 29, Issue 2, January 16, 2026.A versatile electrochemical method for the intramolecular aminobromination of alkenes has been developed. The method provides access to five‐, six‐, and seven‐membered heterocycles by exploiting tetrabutylammonium bromide as an electrolyte and bromine source.
Sara Colombo +9 more
wiley +1 more source