Results 21 to 30 of about 607 (146)
Anticancer and Antimicrobial Activity of Some New 2,3‐Dihydro‐1,5‐benzodiazepine Derivatives
Heteroatom Chemistry, Volume 2023, Issue 1, 2023., 2023 A series of 2,3‐dihydro‐1,5‐benzodiazepine derivatives have been synthesized and characterized using IR, NMR, GC‐MS, single crystal XRD, and microanalysis. The results of their antibacterial activity against methicillin‐resistance Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, Streptococcus mutans, Pseudomonas ...
Felix Odame +7 more
wiley +1 more source
Challenging Atroposelective C–H Arylation
SynOpen, 2020 Atropisomeric molecules are privileged scaffolds, not only as ligands for asymmetric synthesis, but also as biologically active products and advanced materials.
Joanna Wencel-Delord +1 more
doaj +1 more source
(4Z)-1-Propargyl(1,3-Dipropargyl)-4-(2-oxopropylidene)-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one
Molbank, 2006 n ...
Ould Mohamed Sidya Mohamed Said +6 more
doaj +1 more source
Advanced Science, Volume 7, Issue 22, November 18, 2020., 2020 A single‐stranded DNA‐encoded chemical library (DEL) of 366 600 compounds, based on a stereoisomeric scaffold and on a single‐stranded DNA format, allows the isolation of ligands against multiple protein targets. The library can also be hybridized to a complementary DNA strand equipped with a protein binder, in order to generate affinity‐matured ...
Gabriele Bassi +15 more
wiley +1 more source
Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity
ChemMedChem, Volume 15, Issue 12, Page 1078-1088, June 17, 2020., 2020 The polyphenolic natural product rottlerin, isolated from Kamala powder, has been used for centuries in traditional Indian medicine. Among other biological effects, rottlerin has been shown to activate KCNQ1 potassium channels. Rottlerin analogues were synthesized and evaluated electrophysiologically in X. laevis oocytes.
Marco Lübke +10 more
wiley +1 more source
Pd-Catalyzed Allylic C-H Activation to Seven-Membered N,O-Heterocycles [PDF]
, 2021 Pd-catalyzed allylic C-H activation of simple olefins allows an easy entry to seven-membered N,O-heterocycles such as 1,4-benzoxazepines (1,4-BZOs), 1,4-benzodiazepinones (1,4-BZDs) and 1,4-oxazepanes in good to excellent yields.
Velasco Rubio, Álvaro +2 more
core +1 more source
, 2015 To investigate diazepinone analogues as γ-turn mimics, seven 1,4-benzodiazepin-2-ones 6 and fourteen pyrrolo[1,2-d][1,4]benzodiazepin-6-ones 4 and 5 were synthesized from 1-(2-aminophenyl)pent-4-en-1-one (7).
Aurélie A. Dörr (1566439) +1 more
core +3 more sources
Iridium Catalyzed Asymmetric Hydrogenation of Cyclic Imines of Benzodiazepinones and Benzodiazepines
, 2016 Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was achieved with up to 96% ee.
Zhi-Shi Ye (2058556) +5 more
core +2 more sources
Role of Endoplasmic Reticulum Stress in Atherosclerosis and Diabetic Macrovascular Complications
BioMed Research International, Volume 2014, Issue 1, 2014., 2014 Age‐related changes in endoplasmic reticulum (ER) are associated with stress of this cell organelle. Unfolded protein response (UPR) is a normal physiological reaction of a cell in order to prevent accumulation of unfolded and misfolded proteins in the ER and improve the normal ER function.
Dmitry A. Chistiakov +4 more
wiley +1 more source
On the reaction of fused benzodiazepines with alkynes containing electron-withdrawing groups
, 2020 Fused benzodiazepines were found to react with activated alkynes to effect either vinylation of unsubstituted nitrogen atom or dealkylation of nitrogen and its further vinylation.
Khrustalev V.N. +7 more
core +2 more sources