Results 31 to 40 of about 628 (148)
A Rapid One-Pot Ugi Reaction Based Route to Novel Imidazole-Fused Benzodiazepinones
, 2015 A short and efficient synthetic approach has been developed for the synthesis of a variety of imidazole-fused benzodiazepinones. It is based on a Ugi multicomponent reaction strategy and uses various isocyanides to generate the key intermediates for a ...
Chattopadhyay, Partha +2 more
core +1 more source
Archiv der Pharmazie, Volume 358, Issue 7, July 2025.EGFR inhibitors can be made especially effective through binding small‐molecule inhibitors that target the allosteric pocket. Structural and functional analysis affords new insights into the compositions and their molecular connections that afford effective inhibitors. ABSTRACT The epidermal growth factor receptor (EGFR) tyrosine kinase is an important
Surbhi P. Chitnis +7 more
wiley +1 more source
, 1978 Significant correlation in 11 different 1,4-benzodiazepinones has been established between log k2 (the second order rate constant for the reduction of the ‘azepinones’ by sodium borohydride) and their ED50 against leptazol-induced seizures in mice.
Norman M Trieff, V M Sadagopa Ramanujam
core +1 more source
Benzodiazepinone Derivatives as CRTH2 Antagonists
, 2016 Multiple CRTH2 antagonists are currently evaluated in human clinical trials for asthma and chronic obstructive pulmonary disease (COPD). During our lead optimization for CRTH2 antagonists, an observation of an intramolecular hydrogen bond in ortho ...
Alan C. Cheng (606761) +3 more
core +1 more source
Synthesis, Characterization and DFT Studies on Some 2,3-Dihydro-4-Methyl-1H-1,5-Benzodiazepinone and N-Isopropenyl Benzimidazolone Derivatives [PDF]
, 2013 Benzodiazepinones and benzimidazolones have been synthesized by the reaction of o-phenylenediamine with ethylacetoacetate in boiling xylene. Alkylation of the obtained compounds was carried out by reaction with excess of ethyl iodide.
Ridha Ben Said +5 more
core +1 more source
Targeting CBP revers chemoresistance to 5‐FU of CDX2/REG4 double‐positive gastric cancer
Clinical and Translational Medicine, Volume 14, Issue 11, November 2024.
Zhiyuan Fan +15 more
wiley +1 more source
Design and Synthesis of Ligands Targeting the Hepatitis C Virus Internal Ribosome Entry Site [PDF]
, 2016 Benzodiazepinones and cyclopropylquinazolinamines were designed and synthesized with the goal of creating ligands for the subdomain IIa of the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA and thereby inhibiting viral translation.
Charrette, Brian Paul
core
A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl [PDF]
, 1998 Thrombopoietin (TPO) is a cytokine which plays a central role in megakaryopoiesis and platelet production by binding to its cell surface receptor, termed c-Mpl.
Kimura, Tatsuya +11 more
core +1 more source
Evaluation of two pairs of chiral stationary phases: Effects from the length of the achiral spacers
, 2004 Two pairs of chiral stationary phases (CSPs) with different C-2-symmetric central parts were prepared and evaluated by chromatography of a series of structurally different racemates.
Allenmark, S +5 more
core +2 more sources