Results 51 to 60 of about 520 (121)

DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models. [PDF]

J Transl Med
Lin S, Zhang Y, Yao J, Yang J, Qiu Y, Zhu Z, Hua H.   +6 more
europepmc   +1 more source

Effects of Rovalpituzumab Tesirine on Ventricular Repolarization in Patients With Small-Cell Lung Cancer. [PDF]

Clin Transl Sci, 2021
Goldman JW, Barve M, Patel JD, Wozniak A, Dowlati A, Starodub A, Owonikoko TK, Edenfield W, Laurie SA, Da Costa D, Lally S, Koch M, Kosloski MP, Hoffman D, Dy GK.   +14 more
europepmc   +1 more source

Combined inhibition of RAD51 and CHK1 causes synergistic toxicity in cisplatin resistant cancer cells by triggering replication fork collapse. [PDF]

Int J Cancer
Mann J, Niedermayer K, Krautstrunk J, Abbey L, Wiesmüller L, Piekorz RP, Fritz G.   +6 more
europepmc   +1 more source

Imaging with [⁸⁹Zr]Zr-DFO-SC16.56 anti-DLL3 antibody in patients with high-grade neuroendocrine tumours of the lung and prostate: a phase 1/2, first-in-human trial. [PDF]

Lancet Oncol
Tendler S, Dunphy MP, Agee M, O'Donoghue J, Aly RG, Choudhury NJ, Kesner A, Kirov A, Mauguen A, Baine MK, Schoder H, Weber WA, Rekhtman N, Lyashchenko SK, Bodei L, Morris MJ, Lewis JS, Rudin CM, Poirier JT.   +18 more
europepmc   +1 more source

ATR, CHK1 and WEE1 inhibitors cause homologous recombination repair deficiency to induce synthetic lethality with PARP inhibitors. [PDF]

Br J Cancer
Smith HL, Willmore E, Prendergast L, Curtin NJ.   +3 more
europepmc   +1 more source

Fused Indole-Diazepines with a Bridgehead Nitrogen Atom: Synthesis and Pharmaceutical Significance. [PDF]

Drug Des Devel Ther
Zhou M, Yang X, Wang S.
europepmc   +1 more source

A Combination of Flow and Batch Mode Processes for the Efficient Preparation of mGlu_2/3 Receptor Negative Allosteric Modulators (NAMs). [PDF]

Tetrahedron, 2018
Dhanya RP, Herath A, Sheffler DJ, Cosford NDP.   +3 more
europepmc   +1 more source

Rovalpituzumab Tesirine: A Novel DLL3-Targeting Antibody-Drug Conjugate. [PDF]

Drugs R D, 2018
Lashari BH, Vallatharasu Y, Kolandra L, Hamid M, Uprety D.   +4 more
europepmc   +1 more source

The anthelmintic meclonazepam activates a schistosome transient receptor potential channel. [PDF]

J Biol Chem
Park SK, Sprague DJ, Rohr CM, Chulkov EG, Petrow I, Kumar S, Marchant JS.   +6 more
europepmc   +1 more source

[Synthesis and reaction of dihydrofuro[3,4-b][1,5]benzodiazepinones and dihydropyrrolo[3,4-b][1,5]benzodiazepinones].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1987
K, Matsuo, S, Takada, J, Inoue, K, Tanaka   +3 more
openaire   +1 more source