Results 41 to 50 of about 628 (148)

Trifluoromethoxy Substituted Anilines: Metalation as the Key Step for Structural Elaboration

Trifluoromethoxy-substituted anilines undergo hydrogen/lithium permutation (\"metalation\") with optional site selectivity depending on the N-protective group employed. N-tert-Butoxycarbonyl-2- and -4-(trifluoromethoxy)aniline react with tert-BuLi at the
Schlosser, Manfred, Leroux, Frederic, Castagnetti, Eva   +2 more
core   +1 more source

[1,5-Benzodiazepines. III. Synthesis of 2,4-bisdialkylamino-3H-1,5-benzodiazepines].

, 1979
Benzodiazepines I (NRR1 = NMe2, NEt2, pyrrolidino; R2 = SMe) were prepd. by thiolating benzodiazepinones and methylating the thiones. I (R2 = SMe) were aminated to give I (R2 = NMe2, pyrrolidino, piperidino, morpholino).
Roma G, Ermili A., BALBI, ALESSANDRO, Vigevani E   +3 more
core   +1 more source

Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates

, 2015
1,3,4-Benzotriazepin-2-ones garner interest for medicinal applications, in part due to their relationship with benzodiazepinones. Ten 1,3,4-benzotriazepin-2-ones 6 and 19 and six pyrrolo­[1,2]­[1,3,4]­benzotriazepin-6-ones 7 and 23 were prepared in four ...
Antoine Douchez (1457632), William D. Lubell (1288737)   +1 more
core   +1 more source

Research in 7-aminoindazole series: Synthesis of new halo-7 H-4-Methylpyrazolo[l ,5,4-ef] [1,5]benzodiazepin-6-ones and 5H-9-halo-6-methylpyrazolo[1,5,4-ef][1,5]benzodiazepin-4-ones

, 2000
339-345A new class of 7-aminohaloindazoles has been synthesized. Reactivity of the amino groups of these bicyclic systems has been investigated.
Essassi, E M, Lopez, L, Bellan, J, Benchidmi, M, Mansour, A Ibn, Bouadili, A El, Rakib, E M, Lamande, L   +7 more
core  

A comprehensive evaluation between dexmedetomidine and midazolam for intraoperative sedation in the elderly: protocol for a systematic review and meta-analysis of randomized controlled trials. [PDF]

Syst Rev, 2022
Huang C, Li Z, Long Y, Li D, Huang M, Ding B, Zhu W.   +6 more
europepmc   +1 more source

Convenient two-step synthesis of highly functionalized benzo-fused 1,4-diazepin-3-ones and 1,5-diazocin-4-ones by sequential Ugi and intramolecular SNAr reactions

, 2017
Benzodiazepinones are an important family of heterocycles with very attractive pharmacological properties and peptidomimetic abilities. We report herein a rapid and efficient two-step synthesis of polysubstituted 1,4-benzodiazepin-3-ones and 1,5 ...
Biron, Éric, Liang, Xinxia, Vézina-Dawod, Simon, Gerber, Nicolas   +3 more
core   +1 more source

New Class of Benzodiazepinone Derivatives as Pro-Death Agents Targeting BIR Domains in Cancer Cells. [PDF]

Molecules, 2023
Fiore M, Mosconi M, Bonì F, Parodi A, Salis A, Tasso B, Mastrangelo E, Millo E, Cossu F.   +8 more
europepmc   +1 more source

Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition. [PDF]

Bioorg Med Chem Lett, 2023
Lee S, Love MS, Modukuri R, Chatterjee AK, Huerta L, Lawson AP, McNamara CW, Mead JR, Hedstrom L, Cuny GD.   +9 more
europepmc   +1 more source

Microwave-Assisted Post-Ugi Reactions for the Synthesis of Polycycles. [PDF]

Molecules, 2022
Song L, Cai L, Van der Eycken EV.
europepmc   +1 more source

Advances in the Development of Small Molecule Antivirals against Equine Encephalitic Viruses. [PDF]

Viruses, 2023
Ogorek TJ, Golden JE.
europepmc   +1 more source