Results 61 to 70 of about 520 (121)

DNA replication stress as an Achilles' heel of cancer. [PDF]

Oncotarget, 2015
Da-Rè C, Halazonetis TD.
europepmc   +1 more source

Tilivalline- and Tilimycin-Independent Effects of Klebsiella oxytoca on Tight Junction-Mediated Intestinal Barrier Impairment. [PDF]

Int J Mol Sci, 2019
Hering NA, Fromm A, Bücker R, Gorkiewicz G, Zechner E, Högenauer C, Fromm M, Schulzke JD, Troeger H.   +8 more
europepmc   +1 more source

Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor. [PDF]

Neurosci Lett, 2019
Coddou C, Sandoval R, Hevia MJ, Stojilkovic SS.   +3 more
europepmc   +1 more source

Stereoselective [4+3]-Cycloaddition of 2-Amino-β-nitrostyrenes with Azaoxyallyl Cations to Access Functionalized 1,4-Benzodiazepin-3-ones. [PDF]

Molecules
Kim Y, Kim SG.
europepmc   +1 more source

Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms. [PDF]

Nat Microbiol
Osbelt L, Almási ÉDH, Wende M, Kienesberger S, Voltz A, Lesker TR, Muthukumarasamy U, Knischewski N, Nordmann E, Bielecka AA, Giralt-Zúñiga M, Kaganovitch E, Kühne C, Baier C, Pietsch M, Müsken M, Greweling-Pils MC, Breinbauer R, Flieger A, Schlüter D, Müller R, Erhardt M, Zechner EL, Strowig T.   +23 more
europepmc   +1 more source

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A new route to 1H-1,5-benzodiazepinones

Journal of the Chemical Society Chemical Communications, 1981
Dimethyl allene-1,3-dicarboxylates react with o-phenylenediamine to give 1H-1, 5-benzodiazepinones and not benzimidazoles; the transient enamine intermediate shows preference for a 7-exo-trig ring closure.
Feodor Scheinmann
exaly   +2 more sources

Iridium Catalyzed Asymmetric Hydrogenation of Cyclic Imines of Benzodiazepinones and Benzodiazepines

Organic Letters, 2012
Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was achieved with up to 96% ee. This method provides a direct access to synthesize a range of chiral cyclic amines existing in numerous important natural products and clinical drugs.
Zhishi Ye, Yong-Gui Zhou, Gao Kai
exaly   +3 more sources

Soluble polymer-supported synthesis of benzodiazepinones

Bioorganic & Medicinal Chemistry Letters, 2002
Soluble polymer-supported synthetic method provides a highly efficient route for the construction of biologically important 1,5-benzodiazepin-2-ones. A library of N-substituted benzodiazepinones can be readily assembled utilizing S(N)Ar reaction, reduction of nitro group and one-pot cyclization following N-alkylation as the key step in the synthesis ...
Cheng Yi, Wu, Chung Ming, Sun
openaire   +2 more sources

The synthesis of triazolo[1,5-d][1,4]benzodiazepinones and triazolo[4,3-d][1,4]benzodiazepinones, new compounds with cns activity

Tetrahedron Letters, 1976
exaly   +2 more sources

On substituent effect on the benzodiazepinone system

Computational and Theoretical Chemistry, 2012
Abstract Tautomerism, aromaticity, and electron density at ring critical points of substituted benzodiazepinones, composed of condensed 6- and 7-membered rings (7-substituted 1,3-dihydro-benzo[e][1,4]diazepin-2-ones), were studied at the B3LYP/6-31G ∗∗ level. We found that in the gas phase and in water, the N1H tautomers are more stable than the N4H
Grażyna Karpińska, Aleksander P. Mazurek, Jan Cz. Dobrowolski   +2 more
openaire   +1 more source