Results 71 to 80 of about 607 (146)

Reaction Products Revised and Mechanisms Revisited with Machine Learning-Augmented Computational NMR. [PDF]

J Org Chem
Beduru S, Asimbisa E, Novitskiy IM, Kutateladze AG.   +3 more
europepmc   +1 more source

N-1,2,3-Triazole-isatin derivatives: anti-proliferation effects and target identification in solid tumour cell lines. [PDF]

RSC Med Chem, 2022
Busto N, Leitão-Castro J, García-Sosa AT, Cadete F, Marques CS, Freitas R, Burke AJ.   +6 more
europepmc   +1 more source

Reactions of 2,3-dihydro-1,5-benzodiazepinones-2 derivatives quaternization

Vìsnik Dnìpropetrovsʹkogo unìversitetu. Serìâ Hìmìâ, 2014
Показано, что алкилирование 1-алкил-4-метил-2,3-дигидро-1,5-бензодиазепинонов-2 алкилгалогенидами приводит к образованию четвертичных солей.  Установлено, что в отличие от алкилирования незамещенных в положении 1 1,5-бензодиазепинонов-2, для протекания реакции кватернизации необходим большой избыток алкилгалогенида и длительное (18-46 ч) кипячение в ...
openaire   +1 more source

DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models. [PDF]

J Transl Med
Lin S, Zhang Y, Yao J, Yang J, Qiu Y, Zhu Z, Hua H.   +6 more
europepmc   +1 more source

Combined inhibition of RAD51 and CHK1 causes synergistic toxicity in cisplatin resistant cancer cells by triggering replication fork collapse. [PDF]

Int J Cancer
Mann J, Niedermayer K, Krautstrunk J, Abbey L, Wiesmüller L, Piekorz RP, Fritz G.   +6 more
europepmc   +1 more source

Effects of Rovalpituzumab Tesirine on Ventricular Repolarization in Patients With Small-Cell Lung Cancer. [PDF]

Clin Transl Sci, 2021
Goldman JW, Barve M, Patel JD, Wozniak A, Dowlati A, Starodub A, Owonikoko TK, Edenfield W, Laurie SA, Da Costa D, Lally S, Koch M, Kosloski MP, Hoffman D, Dy GK.   +14 more
europepmc   +1 more source

Imaging with [⁸⁹Zr]Zr-DFO-SC16.56 anti-DLL3 antibody in patients with high-grade neuroendocrine tumours of the lung and prostate: a phase 1/2, first-in-human trial. [PDF]

Lancet Oncol
Tendler S, Dunphy MP, Agee M, O'Donoghue J, Aly RG, Choudhury NJ, Kesner A, Kirov A, Mauguen A, Baine MK, Schoder H, Weber WA, Rekhtman N, Lyashchenko SK, Bodei L, Morris MJ, Lewis JS, Rudin CM, Poirier JT.   +18 more
europepmc   +1 more source

[Synthesis and reaction of dihydrofuro[3,4-b][1,5]benzodiazepinones and dihydropyrrolo[3,4-b][1,5]benzodiazepinones].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1987
K, Matsuo, S, Takada, J, Inoue, K, Tanaka   +3 more
openaire   +1 more source

ATR, CHK1 and WEE1 inhibitors cause homologous recombination repair deficiency to induce synthetic lethality with PARP inhibitors. [PDF]

Br J Cancer
Smith HL, Willmore E, Prendergast L, Curtin NJ.   +3 more
europepmc   +1 more source

A Combination of Flow and Batch Mode Processes for the Efficient Preparation of mGlu_2/3 Receptor Negative Allosteric Modulators (NAMs). [PDF]

Tetrahedron, 2018
Dhanya RP, Herath A, Sheffler DJ, Cosford NDP.   +3 more
europepmc   +1 more source