Results 141 to 150 of about 80,603 (326)

Addition of clonidine or dexmedetomidine to bupivacaine prolongs caudal analgesia in children.

open access: yesBritish Journal of Anaesthesia, 2009
BACKGROUND Caudal block is a common technique for paediatric analgesia but with the disadvantage of short duration of action after single injection. Caudal dexmedetomidine and clonidine could offer significant analgesic benefits.
A. El-Hennawy   +4 more
semanticscholar   +1 more source

Advancing antihypertensive drug development

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 15, Page 3389-3410, August 2025.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu   +5 more
wiley   +1 more source

Heroin withdrawal as a possible cause of acute concomitant esotropia in adults [PDF]

open access: yes, 2001
Aim: To report the possible effects of heroin withdrawal on binocular vision. Methods: To present a case series of patients in whom esotropia developed on cessation of heroin use.
Firth, A.Y.
core  

The Effect of Clonidine Pretreatment on Epidural Resiniferatoxin in a Neuropathic Pain Rat Model [PDF]

open access: yes, 2015
Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. Using a rat model
Choi, Sang Sik   +9 more
core   +1 more source

EFFECT OF CLONIDINE ON THE EXCITABILITY OF VASOMOTOR LOCI IN THE CAT [PDF]

open access: green, 1975
B. N. Dhawan   +4 more
openalex   +1 more source

Management of hot flashes in patients who have breast cancer with venlafaxine and clonidine: a randomized, double-blind, placebo-controlled trial.

open access: yesJournal of Clinical Oncology, 2011
PURPOSE Therapies for breast cancer may induce hot flashes that can affect quality of life. We undertook a double-blind, placebo-controlled trial with the primary objective of comparing the average daily hot flash scores in the twelfth week among ...
A. Boekhout   +9 more
semanticscholar   +1 more source

Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders

open access: yesDevelopmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1095-1102, August 2025.
Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells. Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16299 This original article is commented by Thompson on pages 975–976 of this issue. Abstract We report eight children with de novo pathogenic DNA variants in chromatin‐
Russell C. Dale   +14 more
wiley   +1 more source

Single Deficit, Comorbidity or Varying Degrees of Dysfunction? New Directions to the Study of Learning Disorders

open access: yesApplied Cognitive Psychology, Volume 39, Issue 4, July/August 2025.
ABSTRACT Research on neurodevelopmental disorders (NDDs) has led us to refine our theoretical and methodological approaches. We explore whether new deficit clusters in line with the Research Domain Criteria, a novel multifactorial framework, optimally explain known conditions such as ADHD, DLD, or SLD in reading.
Evgenia‐Peristera Kouki   +3 more
wiley   +1 more source

Subarachnoid clonidine and trauma response in cardiac surgery with cardiopulmonary bypass

open access: yesRevista Brasileira de Anestesiologia, 2014
Background and objectives: The intense trauma response triggered by cardiopulmonary bypass can lead to increased morbidity and mortality. The present study evaluated whether clonidine, a drug of the class of α-2 agonists, administered by spinal route ...
Claudia Gissi da Rocha Ferreira   +1 more
doaj   +1 more source

Medication Causes and Treatment of Delirium in Patients With and Without Dementia

open access: yesBrain and Behavior, Volume 15, Issue 7, July 2025.
Medication associated risk related to cause and treatment of delirium ABSTRACT Introduction Medication associated with delirium in adult patients is poorly understood and considered both a predisposing and precipitating factor. Prescribing advice is lacking. This systematic review aims to collate evidence on medication risks in delirium associated with
Anita Elaine Weidmann   +5 more
wiley   +1 more source

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