Results 91 to 100 of about 1,949,061 (374)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

USING OF UNIVERSAL PLASMID CONSTRUCTIONS FOR DESIGN OF RECOMBINANT ANTIBODIES WITH DEFINED SPECIFICITY IN EUKARYOTIC CELLS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Aim. In this study we aimed to develop the methodology to change the antigen specificity of chimeric antibodies by replacing the variable region genes in the previously designed universal plasmid constructions pLK DT-17 and pHG DT-17 encoding the DT-17 ...
T. G. Samartseva, A. S. Oksanich, N. F. Gavrilova, I. V. Yakovleva, V. V. Sviridov, V. V. Zverev   +5 more
doaj   +1 more source

Minimal sets determining universal and phase-covariant quantum cloning

, 2012
We study the minimal input sets which can determine completely the universal and the phase-covariant quantum cloning machines. We find that the universal quantum cloning machine, which can copy arbitrary input qubit equally well, however can be ...
Fan, Heng, Jing, Li, Mu, Liang-Zhu, Shi, Han-Duo, Wang, Yi-Nan   +4 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The Man-Simulacrum – the Human Future in Baudrillard’s Perspective

Проблеми на постмодерността, 2017
The research studies Jean Baudrillard's conception about the merging of simulation and virtuality and its consequence on the notion and perception of man. It focuses on the duplicate-simulacrum of man that Baudrillard depicts in his works.
Gergana Popova
doaj  

Forensic possibilities in protecting victims of voice and speech cloning using artificial intelligence [PDF]

Temida
The rapid advancement of modern technology has facilitated the commission of various types of unlawful acts. The revolution in the field of artificial intelligence (AI) has made this technology widely accessible, significantly increasing ...
Šešum Mia, Šestić Marina
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Sequencing and Phylogenetic Analysis of Potato virus Y Liaoning Isolate in China

Journal of Integrative Agriculture, 2013
Complete genome sequence of Potato virus Y Liaoning isolate (PVY-LN) causing tobacco vein necrosis symptoms were isolated from Liaoning Province in China. Genome sequences of PVY-LN was 9714 nucleotides in length, excluding the 3′-terminal poly (A) tail.
Fang WANG, Zheng-liang GAO, Meng-nan AN, Ben-guo ZHOU, Yuan-hua WU   +4 more
doaj   +1 more source

Experimental linear-optical implementation of a multifunctional optimal qubit cloner

, 2012
We present the first experimental implementation of a multifunctional device for the optimal cloning of one to two qubits. Previous implementations have always been designed to optimize the cloning procedure with respect to one single type of a priori ...
Adam Miranowicz, Antonín Černoch, G. Van Assche, Jan Soubusta, Karel Lemr, Karol Bartkiewicz, L. Gyongyosi, N. J. Cerf   +7 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source