Results 111 to 120 of about 687,759 (305)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

HUMAN CLONING: PAPERS FROM A CHURCH CONSULTATION

open access: yes, 2001
Cloning : can it be good for us / Kevin Fitzgerald -- Table talk and public policy formation in the clone age / Margaret R. Mclean -- Broadening the church's conversation / Richard Perry -- Cloning : the destiny and dangers of being human / Philip ...
Evangelical Lutheran Church in America [ELCA]. Division for Church in Society   +1 more
core  

Human reproductive cloning: a conflict of liberties.

open access: yes, 2010
Proponents of human reproductive cloning do not dispute that cloning may lead to violations of clones' right to self-determination, or that these violations could cause psychological harms.
Havstad, Joyce C.
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

On cloning human beings

open access: yes, 2002
The purpose of this paper is to show that arguments for and against cloning fail to make their case because of one or both of the following reasons: 1) they take for granted customary beliefs and assumptions that are far from being unquestionable; 2 ...
de Melo-Martín, Inmaculada
core  

Cloning, expression, and purification of recombinant Enterotoxin B and cholera toxin B fusion protein in Lactobacillus plantarum [PDF]

open access: yesMedical Laboratory Journal
Background: Lactic acid bacteria (LAB) are promising platforms for mucosal vaccine development. Staphylococcus aureus enterotoxin B (SEB), a potent superantigen, is associated with food poisoning and toxic shock syndrome.
Fatemeh Maghsood Ahmadi   +4 more
doaj  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

HUMAN DIGNITY AND HUMAN CLONING

open access: yes, 2004
Preface / Silja Vöneky and Rüdiger Wolfrum -- List of contributors -- List of abbreviations -- Pt. 1. Human creation and human dignity in religious and ethical perspectives -- Ch. 1. The creation and the dignity of man in Islam / Reza Sheikholeslami -

core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

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