Results 91 to 100 of about 630,776 (310)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
HumanitiesThis article will critically appraise the extent to which new developments in the fields of reproductive technology are shown to impact female bodily autonomy and reproductive choice in Eva Hoffman’s novel The Secret.
Laura-Jane Devanny
doaj +1 more source
British Medical Bulletin, 2018 Scientists have cloned animals since the late 19th century, but the crucial step for ethics was the cloning of the first mammal by somatic cell nuclear transfer in 1997. This suggested that scientists could also clone, and possibly enhance, human beings.This survey examines ethical literature on cloning since the 1960s.The one ethical area of agreement
openaire +3 more sources
, 2002 The purpose of this paper is to show that arguments for and against cloning fail to make their case because of one or both of the following reasons: 1) they take for granted customary beliefs and assumptions that are far from being unquestionable; 2 ...
de Melo-Martín, Inmaculada
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
The Man-Simulacrum – the Human Future in Baudrillard’s Perspective
Проблеми на постмодерността, 2017 The research studies Jean Baudrillard's conception about the merging of simulation and virtuality and its consequence on the notion and perception of man. It focuses on the duplicate-simulacrum of man that Baudrillard depicts in his works.
Gergana Popova
doaj
HUMAN CLONING: PAPERS FROM A CHURCH CONSULTATION
, 2001 Cloning : can it be good for us / Kevin Fitzgerald -- Table talk and public policy formation in the clone age / Margaret R. Mclean -- Broadening the church's conversation / Richard Perry -- Cloning : the destiny and dangers of being human / Philip ...
Evangelical Lutheran Church in America [ELCA]. Division for Church in Society +1 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source