Results 91 to 100 of about 7,005 (218)

The role of liver fluke invasion in the pathogenesis of cholangiocarcinoma

Clinical & Experimental Hepatology
Infections with the liver flukes Clonorchis sinensis and Opisthorchis viverrini are currently endemic in Southeast and East Asia. Their limited ecological and geographical distribution is caused by environmental factors and culinary habits of the human ...
Martyna Bykowska-Tumasz, Katarzyna Sikorska   +1 more
doaj   +1 more source

An immunoregulatory amphipathic peptide derived from Fasciola hepatica helminth defense molecule (FhHDM‐1.C2) exhibits potent biotherapeutic activity in a murine model of multiple sclerosis

The FASEB Journal, Volume 39, Issue 4, 28 February 2025.
Using a combination of bioinformatics, sequence and structural analyses, we designed derivatives of the parasite‐derived helminth defense molecule to determine a relationship between the peptide structure and its immune regulatory function. Screening these derivatives in a series of assays related to the activation of inflammatory macrophages, we ...
Richard Lalor, Akane Tanaka, Jenna Shiels, Aakanksha Dixit, Sabine Hoadley, Eloïse Dufourd, Siobhan Hamon, Joyce To, Clifford C. Taggart, Sinead Weldon, Bronwyn O'Brien, Judith Greer, John P. Dalton, Sheila Donnelly   +13 more
wiley   +1 more source

A schistosome [beta] subunit remodels inactivation of a calcium channel _via_ an N-terminal polyacidic motif [PDF]

, 2010
The beta subunit of high voltage-activated Ca (Cav) channels targets the pore forming [alpha]~1~ subunit to the plasma membrane and defines the biophysical phenotype of the Cav channel complex. Cav channel inactivation following activation and opening is
Robert M. Greenberg, Vicenta Salvador-Recatala   +1 more
core   +1 more source

Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology [PDF]

, 2017
Helminth parasites are highly prevalent in many low- and middle-income countries, in which inflammatory bowel disease and other immunopathologies are less frequent than in the developed world.
Fleming, John O., Maizels, Richard, Varyani, Fumi   +2 more
core   +1 more source

EZH2‐Mediated PHF10 Suppression Amplifies HMGB1/NF‐κB Axis That Confers Chemotherapy Resistance in Cholangiocarcinoma

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Chemoresistance represents a major threat to the treatment of human cancers, including cholangiocarcinoma (CHOL). Aberrant epigenetic events contribute most to the progression of CHOL and chemotherapy efficacy. PHF10, one subunit of SWI/SNF complex, expressed highly in tumours that correlated with tumorigenesis.
Qiushi Yin, Daning Lin, Weiqian Zeng, Shijing Gu, Chuangshi Zhu, Changfu Liang, Yan Yang   +6 more
wiley   +1 more source

Ultrastructure of the integument of adult Clonorchis sinensis [PDF]

The Korean Journal of Parasitology, 1968
Ultrastructural studies on the integument of digenetic trematodes were investigated by several workers (Senft et al., 1961; Bjorkman and Thorsell, 1964; Burton, l966; Erasmus, l968; Morris and Threadgold, 1967, l968). Clonorchis sinensis is a common parasite of human beings in the Far East.
openaire   +2 more sources

World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010 [PDF]

, 2015
Illness and death from diseases caused by contaminated food are a constant threat to public health and a significant impediment to socio-economic development worldwide.
Adegoke, Gabriel O., Afshari, Reza, Alasfoor, Deena, Angulo, Frederick J., Aspinall, Willy, Baines, Janis, Balakrishnan, Kalpana, Bellinger, David C., Bolger, P. Michael, Buchanan, Robert, Budke, Christine, Caipo, Marisa L., Carabin, Hélène, Cawthorne, Amy, Chaicumpa, Wanpen, Cole, Dana, Cooke, Roger M., Cravioto, Alejandro, Crump, John A., de Noordhout, Charline Maertens, de Silva, Nilanthi R., Devleesschauwer, Brecht, Döpfer, Dörte, Ehiri, John E., El-Jardali, Fadi, Fazil, Aamir, Ferreccio, Catterina, Fischer-Walker, Christa, Fèvre, Eric M., Fürst, Thomas, Gargouri, Neyla, Gibb, Herman J., Haagsma, Juanita A., Hald, Tine, Hall, Aron J., Hall, Gillian, Hamza, Wan Mansor Bin, Havelaar, Arie H., Henao, Olga, Hoffmann, Sandra, Jensen, Helen, Jessani, Nasreen, Kasuga, Fumiko, Keddy, Karen H., Kirk, Martyn D., Koopmans, Marion P G, Lake, Robin J., Lanata, Claudio F., Lei, Haicho, Levine, Myron M., Liu, Xiumei, Majowicz, Shannon, Manyindo, Ben, Mathers, Colin, McDonald, Scott A., Nasinyama, George, Ongolo-Zogo, Pierre, Pires, Sara, Pitt, John I., Praet, Nicolas, Rokni, Mohammad B., Scallan, Elaine, Speybroeck, Niko, Sripa, Banchob, Sripa, Banchob, Stein, Claudia, Thomas, M. Kate, Torgerson, Paul R., van Leeuwen, Rolaf, Verger, Philippe, Verhoef, Linda, Willingham, Arve Lee, Wu, Felicia, Zeilmaker, Marco, Zhou, Xiao Nong   +74 more
core   +2 more sources

The use of Hetol on the infection of Clonorchis sinensis

The Korean Journal of Parasitology, 1966
The 16 cases of Clonorchis sinensis infection were divided into 6 groups, according to the method of administration of 1, 4-Bis-trichlormethyl-benzol. The number of egg-out and clinical manifestation of pre.and post drug administration were observed. 1.
Moo Joon, Cho, Kee Mok, Cho, Chin Thak, Soh   +2 more
openaire   +2 more sources

Rapid Detection and Differentiation of Clonorchis sinensis and Opisthorchis viverrini Using Real-Time PCR and High Resolution Melting Analysis

The Scientific World Journal, 2014
Clonorchis sinensis and Opisthorchis viverrini are both important fish-borne pathogens, causing serious public health problem in Asia. The present study developed an assay integrating real-time PCR and high resolution melting (HRM) analysis for the ...
Xian-Quan Cai, Hai-Qiong Yu, Rong Li, Qiao-Yun Yue, Guo-Hua Liu, Jian-Shan Bai, Yan Deng, De-Yi Qiu, Xing-Quan Zhu   +8 more
doaj   +1 more source

Progress on the development of rapid diagnostic tests for foodborne neglected zoonotic helminthiases : a systematic review [PDF]

, 2019
Background: Foodborne Neglected Zoonotic Helminths (FNZH) are parasites of both economic and public health importance. They include Taenia solium, Echinococcus granulosus sensu lato, Echinococcus multilocularis and Foodborne trematodes (FBT).
Chabala, Chishala, Dorny, Pierre, Gabriël, Sarah, Mubanga, Chishimba, Mwape, Kabemba E, Phiri, Isaac K, Schmidt, Veronika, Trevisan, Chiara, Van Damme, Inge, Zulu, Gideon   +9 more
core   +1 more source