Results 11 to 20 of about 8,597 (260)

Ivermectin Identified Using a High-Throughput Screening System Exhibits Anti-Clonorchis sinensis Activity in Rats [PDF]

Antibiotics
Background: Clonorchiasis, caused by the parasite Clonorchis sinensis, remains a public health concern in East Asian countries. Methods: In this study, high-throughput screening was used to analyze 320 compounds for potential inhibitory activity against ...
Soon-Ok Lee, Hyeryon Lee, Ki Back Chu, Jianhua Li, Sung-Jong Hong, Sung Soo Kim, Joo Hwan No, Fu-Shi Quan   +7 more
doaj   +2 more sources

IL-10 regulates Th17 response to inhibit hepatobiliary injury caused by Clonorchis sinensis infection in C57BL/6J mice [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Clonorchiasis caused by Clonorchis sinensis is a mainly foodborne parasitic disease. It can lead to hepatobiliary duct inflammation, fibrosis, obstructive jaundice, liver cirrhosis, and even cholangiocarcinoma. Interleukin (IL)-10 is an immune-regulatory
Beibei Zhang, Jianling Wang, Man Liu, Qianqian Zhao, Guozhi Yu, Bo Zhang, Hui Hua, Jinyao Xu, Jing Li, Qian Yu, Stephane Koda, Yin-Hai Xu, Zhihua Jiang, Chao Yan, Kui-Yang Zheng   +14 more
doaj   +2 more sources

Clonorchis sinensis infection amplifies hepatocellular carcinoma stemness, predicting unfavorable prognosis.

PLoS Neglected Tropical Diseases
BackgroundExtensive evidence links Clonorchis sinensis (C. sinensis) to cholangiocarcinoma; however, its association with hepatocellular carcinoma (HCC) is less acknowledged, and the underlying mechanism remains unclear.
Qiumei Lin, Zeli Tang, Yuling Qin, Xueling Deng, Caibiao Wei, Fengfei Liu, Xiaolan Pan, Dengyu Liu, Tingzheng Zhan, Min Fang   +9 more
doaj   +3 more sources

Marked mitochondrial genetic variation in individuals and populations of the carcinogenic liver fluke Clonorchis sinensis.

PLoS Neglected Tropical Diseases, 2020
Clonorchiasis is a neglected tropical disease caused by the Chinese liver fluke, Clonorchis sinensis, and is often associated with a malignant form of bile duct cancer (cholangiocarcinoma).
Liina Kinkar, Pasi K Korhonen, Daxi Wang, Xing-Quan Zhu, Galina N Chelomina, Tao Wang, Ross S Hall, Anson V Koehler, Ivon Harliwong, Bicheng Yang, J Lynn Fink, Neil D Young, Robin B Gasser   +12 more
doaj   +3 more sources

Clonorchis sinensis extracellular vesicles associated with Csi-let-7a-5p activate pro-inflammatory macrophages to induce biliary injury. [PDF]

PLoS Negl Trop Dis
Zhang B, Li X, Zhou QY, Zhang C, Bian ZR, Ren XX, Yu Q, Hua H, Jiang Z, Zhang B, Li XY, Chen MX, Zheng KY, Yan C.   +13 more
europepmc   +2 more sources

Systems biology studies of adult Paragonimus lung flukes facilitate the identification of immunodominant parasite antigens [PDF]

, 2014
Paragonimiasis is a food-borne trematode infection acquired by eating raw or undercooked crustaceans. It is a major public health problem in the far East, but it also occurs in South Asia, Africa, and in the Americas. Paragonimus worms cause chronic lung
Curtis, Kurt C, Fischer, Peter U, McNulty, Samantha N, Mitreva, Makedonka, Townsend, R Reid, Weil, Gary J   +5 more
core   +8 more sources

Omega-Class Glutathione Transferases Protect DNA from Oxidative Stress in Pathogenic Helminth Reproductive Cells

Antioxidants, 2023
Pathogenic helminths have evolved mechanisms to preserve reproductive function while surviving long-term in the host via robust protective responses.
Jeong-Geun Kim, Insug Kang, Chun-Seob Ahn, Woon-Mok Sohn, Yoon Kong   +4 more
doaj   +1 more source

Clonorchis sinensis aggravates biliary fibrosis through promoting IL-6 production via toll-like receptor 2-mediated AKT and p38 signal pathways

PLoS Neglected Tropical Diseases, 2023
Clonorchis sinensis is an important food-borne zoonotic parasite which has been linked to biliary fibrosis and cholangiocarcinoma. However, the details of the pathogenesis of C. sinensis were unclear.
Yuru Wang, Xu Zhang, Xiaocen Wang, Nan Zhang, Yanhui Yu, Pengtao Gong, Xichen Zhang, Yeting Ma, Xin Li, Jianhua Li   +9 more
doaj   +2 more sources

Marked elevation of serum alpha-fetoprotein following Clonorchis sinensis infection: A rare case report

Liver Research, 2022
Clonorchiasis, also known as the liver fluke disease, is caused by eating raw freshwater fish or shrimps that contain Clonorchis sinensis cyst larvae, which mainly involves the hepatobiliary system. Chronic abdominal pain and distention, loss of appetite,
Ying Lin, Xiaodan Zong, Mingkai Li, Sizhe Wan, Hongsheng Yu, Xiuqing Wei   +5 more
doaj   +1 more source

Cercarial chaetotaxy of Clonorchis sinensis [PDF]

The Korean Journal of Parasitology, 1988
The pattern of sensory papillae, chaetotaxy, of the cercaria of Clonorchis sinensis was observed. The chaetotaxy was as follows; 5-6 Ci l, 4-5 Ci 2, 5-6 Ci 3 at lst row, 4 Cii 1, 2 Cii 2, 4 Cii 3, 5-6 Cii 4 at 2nd row, 3-4 Ciii 1, 2-3 Ciii 2 at 3rd row, and 2 Civ 1, 2-3 Civ 2, 2-3 Civ 3, at 4th row, in cephalic region; 2 AiV, l AiD, 2 AiiV, 1 AiiD, 2 ...
Duk Young, Min, Jae Jin, Kim
openaire   +2 more sources