Results 51 to 60 of about 3,567,567 (271)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The rise of close reading [PDF]

, 2016
The purpose of this advanced literature review is to examine the evolution of close reading as a reading strategy. Currently, close reading is a strategy used to teach students to independently navigate through challenging text.
Larsen, Jayne E.
core   +1 more source

Nuevos enfoques a la novela: de Terra Nostra a la twitter-literatura

Co-herencia: Revista de Humanidades, 2015
Este artículo aborda nuevos enfoques al género de la novela en el siglo XXI. Al inicio sustenta que incluso los críticos contemporáneos más vanguardistas de finales del siglo XX e inicios del XXI, comparten una característica fundamental: un referente en
Raymond L. Williams
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Więzy czasu. Queerowe tymczasowości i queerowe historie

Teksty Drugie, 2023
In a preface to her book, Freeman begins from Robert Graves’s poem “It’s A Queer Time.” Freeman finds many chapters of her book answers to the poem. She explains that the introduction to her book projects a theory on the interconnectedness of time and ...
Elisabeth Freeman
doaj  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Rencontres et réceptions avec Marine Picon : quel est le fondement de la connaissance ?

Lexicon Philosophicum
The purpose of this note is to explore the theme of language as an object of reception, to highlight the interrelationship between some key concepts, and to sketch, however briefly, a conceptual thread that will allow us to present some of the points of ...
Cristina Marras
doaj   +1 more source

Close Reading a Close Reading

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Mystery House is a game that was released in 1980 for the Apple II computer. It was the first text adventure game known to be illustrated and was the game design debut of celebrated game designer Roberta Williams. The landmark 2008 book Mechanisms: New Media and the Forensic Imagination performed a close reading of a Mystery Housefloppy disk, and in ...
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source