Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Semi-Closed-Form Solution of Near-Minimum-Time Spin-to-Spin Attitude Maneuvers
AerospaceHigh-agility spacecraft require time-efficient attitude maneuvers under strict actuator- and system-driven saturation limits on angular rate and angular acceleration.
Seong-Hyeon Jo, Sung-Hoon Mok
doaj +1 more source
Accurate closed-form solution of the SIR epidemic model. [PDF]
Physica D, 2020 Barlow NS, Weinstein SJ.
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
TMD-Inerter for Tall Building Damping: Approximate Closed-Form Solution, Performance and Conclusions
BuildingsThis paper analyzes the performance of the TMD-Inerter for tall building damping. The analysis is performed by simulation to ensure ideal working behaviour of the inerter, i.e., the inerter produces a force in proportion to the relative acceleration of ...
Felix Weber
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Three-dimensional organ extraction method for color volume image based on the closed-form solution strategy. [PDF]
Quant Imaging Med Surg, 2020 Liu B, Zhang X, Yang L, Zhang J.
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A Refined Theory for Characterizing Adhesion of Elastic Coatings on Rigid Substrates Based on Pressurized Blister Test Methods: Closed-Form Solution and Energy Release Rate. [PDF]
Polymers (Basel), 2020 Lian YS +4 more
europepmc +1 more source