Results 101 to 110 of about 529,491 (346)

The closed-loop economy

open access: yesInternational Journal of Design & Nature and Ecodynamics, 2016
The economy is modeled as an engineering pumping system. At the start, no control is used; thus, the open-loop system is established. Flow, or analogously GDP, is sent from a pump to a storage tank (analogously, inventories). Control is then applied where investment (flow out of the tank) is controlled via the interest rate. Thus, the open loop becomes
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Closed-loop functional optogenetic stimulation

open access: yesNature Communications, 2018
Optogenetics is a promising alternative approach for restoration of neuromuscular function. Here the authors establish a closed-loop functional optogenetic stimulation for the control of limb joint angle in murine models, which demonstrates improved ...
Shriya S. Srinivasan   +4 more
doaj   +1 more source

NONRENEWABLE RESOURCE OLIGOPOLIES AND THE CARTEL-FRINGE GAME [PDF]

open access: yes
We specify and solve a closed-loop dominant firm nonrenewable resource game, with a price-taking fringe. We show that (i) the outcomes of the closed-loop and the open-loop dominant firm nonrenewable resource game (a la Salant 1976) coincide and (ii) when
Cees Withagen, Hassan Benchekroun
core  

Design and Operational Modifications to Model IV FCCUs to Improve Dynamic Performance [PDF]

open access: yes, 1994
Model IV Fluid Catalytic Cracking Units (FCCUs) differ from other cracking units in that model IV FCCUs do not have slide valves in the catalyst circulation lines to enable direct control of catalyst circulation rate through the unit.
Huq, Iftikhar   +2 more
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Closed loop electrostatic levitation system [PDF]

open access: yes, 1985
An electrostatic levitation system is described, which can closely control the position of objects of appreciable size. A plurality of electrodes surround the desired position of an electrostatically charged object, the position of the objects is ...
Elleman, D. D.   +2 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Theoretical justification and error analysis for slender body theory with free ends

open access: yes, 2019
Slender body theory is a commonly used approximation in computational models of thin fibers in viscous fluids, especially in simulating the motion of cilia or flagella in swimming microorganisms.
Mori, Yoichiro   +2 more
core   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

open access: yesFEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde   +3 more
wiley   +1 more source

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