Results 91 to 100 of about 906,185 (256)

Closed-Loop Transfer Enables AI to Yield Chemical Knowledge

, 2023
AI-guided closed-loop experimentation has recently emerged as a promising method to optimize objective functions,1,2 but the substantial potential of this traditionally black-box approach to reveal new scientific knowledge has remained largely untapped ...
Seungjoo, Yi, Nicholas, Jackson, Edward, Jira, Ying, Diao, Tiara, Torres-Flores, Alàn, Aspuru-Guzik, David, Friday, Charles, Schroeder, Austin, Cheng, Wesley, Wang, Changhyun, Hwang, Martin, Burke, Nicholas, Angello   +12 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Penerapan Kendali Fuzzy dalam Pengembangan Stimulasi Listrik untuk Mempercepat Penyembuhan Luka

Jurnal Nasional Teknik Elektro dan Teknologi Informasi
Penyembuhan luka kronis masih menjadi tantangan medis karena keterbatasan terapi konvensional dalam mempercepat regenerasi jaringan. Stimulasi listrik (electrical stimulation, ES) dapat menjadi solusi efektif, tetapi ES open-loop belum mampu menyesuaikan
Rahmawati, Achmad Arifin, Duti Sriwati Aziz, Gunawan, Raisah Hayati, Siti Amra   +5 more
doaj   +1 more source

Closed-loop step response for individual SISO systems.

, 2016
Closed-loop step response for individual SISO systems.
Coşku Kasnakoğlu (3270132)
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Coordinative operations of distributed decision-making closed-loop supply chain: A review

, 2011
The problems and the causes of distributed decision-making in closed-loop supply chain are analysed in this paper. The importance and the significant of the researches for coordinate operations policy design for distributed decision-making closed-loop ...
Zhang Y(张毅), Liu B(刘彬), Xu JW(徐家旺), Zhao LQ(赵礼强)   +3 more
core   +1 more source

MODERATE-DENSITY CLOSE-CLOSED LOOP BURST ERROR DETECTING CODES

Ratio Mathematica, 2003
In this paper, we study cyclic codes detecting a subclass of close-closed loop bursts viz. moderate-density close-closed loop bursts. A subclass of CT close-closed loop bursts called CT moderate-density close-closed loop bursts is also studied.
Bal Kishan Dass, Sapna Jain
doaj  

Build instructions for Closed-loop Spectroscopy Lab: Light-mixing Demo

, 2023
Closed-loop Spectroscopy Lab: Light-mixing Demo (CLSLab:Light) is a teaching and prototyping platform for autonomous scientific discovery. It consists of a set of LEDs and a light sensor while encapsulating key principles for "self-driving" (i.e ...
Taylor D., Sparks, Sterling G., Baird
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source