Results 101 to 110 of about 1,444,267 (298)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Closed loop supply chain in printing operation
Revista Produção Online, 2011 There is a clear change in focus in large companies, previously dedicated primarily to the production of physical goods, toward offering complimentary services and changing their focus toward more service-oriented businesses, in order to increase their ...
Marcius Fabius Henriques Carvalho +2 more
doaj +1 more source
A change-detection algorithm for short-circuit fault detection in closed-loop AC drives [PDF]
, 2013 This paper deals with an on-line method for turn-to-turn short-circuit fault detection in low-voltage permanent-magnet synchronous machine drives. Due to the closed-loop control, the fault effects are reflected in the voltage.
Johan Gyselinck +10 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Closed-loop step response for individual SISO systems.
, 2016 Closed-loop step response for individual SISO systems.
Coşku Kasnakoğlu (3270132)
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Closed-Loop Supply Chains in Circular Economy Business Models
, 2019 With the emergence of the circular economy (CE) approach into business models, there is need for deeper understanding of resource loops activities and how current supply chains can support the development of emerging CE business models. However, there is
Maria Holgado +3 more
core +2 more sources
Performance Parameters of a Closed Loop Thermosyphon
, 2012 Devices composed of output electronic components produce waste heat that has to be dissipated to the environment. Heat removal by means of forced convection air cooling is quite often insufficient and new alternatives for cooling of output electronic ...
Martin Smitka +3 more
core +1 more source