Results 101 to 110 of about 906,185 (256)

Closed loop peer review [PDF]

open access: yesEMBO reports, 2018
EMBO Reports (2019) 20: e47437[OpenUrl][1][FREE Full Text][2] When preparing for that important interview or your big night out, you might first carefully select and then lay out and check your outfit. After spending far too much time making yourself look just so, you will then probably take a final review in the mirror before legging it for your taxi,
openaire   +2 more sources

Performance Parameters of a Closed Loop Thermosyphon

open access: yes, 2012
Devices composed of output electronic components produce waste heat that has to be dissipated to the environment. Heat removal by means of forced convection air cooling is quite often insufficient and new alternatives for cooling of output electronic ...
Martin Smitka   +3 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Closed-Loop Supply Chains in Circular Economy Business Models

open access: yes, 2019
With the emergence of the circular economy (CE) approach into business models, there is need for deeper understanding of resource loops activities and how current supply chains can support the development of emerging CE business models. However, there is
Maria Holgado   +3 more
core   +2 more sources

Closed-loop functional optogenetic stimulation

open access: yesNature Communications, 2018
Optogenetics is a promising alternative approach for restoration of neuromuscular function. Here the authors establish a closed-loop functional optogenetic stimulation for the control of limb joint angle in murine models, which demonstrates improved ...
Shriya S. Srinivasan   +4 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Closed-loop 4D-printed soft robots

open access: yes, 2020
Closed-loop 4D-printed soft ...
Abbas Kouzani (13079637)   +2 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

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