Results 51 to 60 of about 812,697 (276)

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Scaling of the divertor power spreading (S-factor) in open and closed divertor operation in JET and ASDEX Upgrade

Journal of Nuclear Materials, 2015
Abstract An experimental database of the power spreading into the target private flux region (S-factor) from ASDEX Upgrade and JET outer target data has been gathered and analysed. The power spreading, combined with the Scrape-Off Layer heat flux decay length λ q , determines the power exhaust channel width at the divertor target.
Scarabosio, A., Eich, T., Hoppe, F., Paradela, I., Sieglin, B., Reimold, F., Rack, M., Groth, Mathias, Wischmeier, M., Arnoux, G., Balboa, I., Marsen, S., the ASDEX Upgrade Team, JET-EFDA contributors   +13 more
openaire   +5 more sources

Role of turbulent separatrix tangle in the improvement of the integrated pedestal and heat exhaust issue for stationary-operation tokamak fusion reactors

Nuclear Fusion
The magnetic separatrix surface is designed to provide the final and critical confinement to the hot stationary-operation core plasma in modern tokamak reactors in the absence of an external magnetic perturbation (MP) or transient magneto-hydrodynamic ...
C.S. Chang, S. Ku, R. Hager, J. Choi, D. Pugmire, S. Klasky, A. Loarte, R.A Pitts   +7 more
doaj   +1 more source

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

2D distribution of hydrogen/impurity radiation and flow formation in stochastic layer during detachment transition in LHD

Nuclear Materials and Energy, 2017
2D distribution of hydrogen/impurity radiation and impurity flow have been measured in the edge stochastic layer of LHD during detachment transition by using a newly developed visible spectrometer system with 130 channel optic fiber array.
M. Kobayashi, S. Morita, M. Goto
doaj   +1 more source

The impact of ELMs on the ITER divertor [PDF]

, 1998
Edge-Localized-Modes (ELMs) are expected to present a significant transient flux of energy and particles to the ITER divertor. The threshold for ablation of the graphite target will be reached if the ELM transient exceeds Q/t{sup 1/2} {approximately} 45 ...
Herrmann, A., Osborne, T.H., Hermann, A., Osborne, T., Lingertat, J., Leonard, A., Suttrop, W., Itami, K., Leonard, A.W., Loarte, A.   +9 more
core   +1 more source

Island divertor configuration design for a quasi-axisymmetric stellarator CFQS [PDF]

, 2020
0000-0002-8156-8233A magnetic field configuration of an island divertor for a quasi-axisymmetric stellarator (CFQS) is proposed. The configuration incorporates large islands surrounding the core confinement region.
LIU, Haifeng, Xiong, G., XU, Yuhong, SHIMIZU, Akihiro, KINOSHITA, Shigeyoshi, ISOBE, Mitsutaka, OKAMURA, Shoichi   +6 more
core   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source